AZD2461

Base Information

Chemical Name:AZD2461
CAS No.:1174043-16-3
Molecular Formula:C22H22FN3O3
Molecular Weight:395.433
Hs Code.:
Mol file:1174043-16-3.mol

Synonyms:4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one;

Suppliers and Price of AZD2461

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one
50mg
$ 1540.00

TRC
4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one
5mg
$ 195.00

Tocris
AZD2461 ≥98%(HPLC)
10
$ 107.00

Tocris
AZD2461 ≥98%(HPLC)
50
$ 446.00

DC Chemicals
AZD2461 >98%
1 g
$ 1200.00

DC Chemicals
AZD2461 >98%
250 mg
$ 600.00

DC Chemicals
AZD2461 >98%
100 mg
$ 300.00

Crysdot
AZD-2461 98+%
100mg
$ 260.00

ChemScene
AZD-2461 98.21%
100mg
$ 250.00

ChemScene
AZD-2461 98.21%
50mg
$ 150.00

Total 23 raw suppliers

Chemical Property of AZD2461

Chemical Property:

PKA:12.07±0.40(Predicted)
PSA：75.55000
Density:1.33±0.1 g/cm3(Predicted)
LogP:3.25420
Storage Temp.:2-8°C
Solubility.:insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥45.2 mg/mL in EtOH with ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor.

Technology Process of AZD2461

There total 2 articles about AZD2461 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.9%

: 763114-26-7
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

: 4045-25-4
4-methoxypiperidine hydrochloride

: 1174043-16-3
4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 - 23 ℃; Product distribution / selectivity;

Reference yield: 61.6%

: 763114-26-7
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

: 4045-24-3
4-methoxypiperidine

: 1174043-16-3
4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In DMA; at 20 ℃; for 21h; Product distribution / selectivity;