4045-25-4

Basic information

• Product Name: 4-Methoxypiperidine hydrochloride
• Synonyms: 4-METHOXY-PIPERIDINE HYDROCHLORIDE;4-Methoxypiperidine hydr...;4-Methoxypiperidine Monohydrochloride;4-Methoxypiperidine HCl;Piperidine, 4-methoxy-, hydrochloride (1:1);4-methoxy-1l2-piperidinehydrochloride;EOS-62183
• CAS NO: 4045-25-4
• Molecular Formula: C₆H₁₃NO*ClH
• Molecular Weight: 151.63
• Mol File: 4045-25-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 137.5-139.5 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Methoxypiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxypiperidine hydrochloride(4045-25-4)
• EPA Substance Registry System: 4-Methoxypiperidine hydrochloride(4045-25-4)

Safety Data

• Statements: 20-22-36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 4045-25-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1S/C6H13NO.ClH/c1-8-6-2-4-7-5-3-6;/h6-7H,2-5H2,1H3;1H

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 74-88-4 methyl iodide 
• 188622-27-7 tert-butyl 4-methoxypiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 474707-27-2 1-(6-bromo-4-quinolyl)-4-piperidyl methyl ether 
• 859217-96-2 5-(4-methoxypiperidin-1-yl)-2-nitrophenol 
• 155849-43-7 1,2-Dihydro-5-(4-methoxypiperidin-1-yl)-3H-1-methyl-1,4-benzodiazepin-2-one 
• 1152986-56-5 3-amino-N-methyl-4-[4-(methyloxy)-1-piperidinyl]benzenesulfonamide 
• 1351089-37-6 N-methyl-4-[4-(methyloxy)-1-piperidinyl]-3-(1H-purin-6-ylamino)benzenesulfonamide 
• 1351094-54-6 N-methyl-4-[4-(methyloxy)-1-piperidinyl]-3-nitrobenzenesulfonamide 
• 1621171-29-6 (4-methoxypiperidinium-1-yl)methyltrifluoroborate 
• 930603-98-8 4-methoxy-1, 4′-bipiperidine 
• 911300-76-0 2-[3-(4-methoxy-1-piperidinyl)propyl]-1H-isoindole-1,3(2H)-dione 
• 911300-77-1 3-(4-methoxy-1-piperidinyl)propylamine 
• 911300-68-0 (4-methoxy-1-piperidinyl)acetonitrile 

Relevant articles and documents

FUSED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF

The present invention relates to fused heterocyclic derivatives, processes for their preparation and their use in medicine. Specifically, the present invention relates to a novel derivative represented by the formula (I′), or its pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the derivative or its pharmaceutically acceptable salt thereof, and the method for preparing the derivative and its pharmaceutically acceptable salt thereof. The present invention also relates to the use of the derivative and its pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the derivative and its pharmaceutically acceptable salt thereof in the preparation of medicines, in particularly as IDO inhibitor medicines, for treating and/or preventing cancers. Wherein each substituent of the formula (I′) is the same as defined in the specification.

COMPOUNDS AND METHODS

Disclosed are compounds having the Formula (I), wherein X, Y, Z, R1, R2 and R3 are as defined herein, and methods of making and using the same.

FUSED HETEROCYCLIC COMPOUND

A compound of the formula: wherein ring'' A is a 7-membered or 8-membered nitrogen- containing ring optionally further substituted, ring B is an optionally substituted aryl group or an optionally substituted heteroaryl group, X1 is a group represented by -NR3-Y1-, -0-, -S-, -SO-, -SO2- or -CHR3- wherein R3 is a hydrogen atom or'' an optionally substituted aliphatic hydrocarbon group, or R3 may be bonded to the carbon atom of ring B to form an optionally substituted ring structure, and Y1 is a bond or an optionally substituted C1-4 alkylene, R1 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom or a sulfur atom, the formula = shows a single bond or a double bond, when ===R2 is - R2, R2 is a hydrogen atom, or an optionally substituted group bonded via a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, and when ===R2 is =R2, R2 is an oxo group, an optionally substituted alkylidene group, or an optionally, substituted imino group.