Benzaldehyde, 3-broMo-2-fluoro-4-Methoxy-

Base Information

• Chemical Name: Benzaldehyde, 3-broMo-2-fluoro-4-Methoxy-
• CAS No.: 1155877-70-5
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Mol file: 1155877-70-5.mol

Synonyms:Benzaldehyde, 3-bromo-2-fluoro-4-methoxy-;3-bromo-2-fluoro-4-methoxy-benzaldehyde;

Chemical Property of Benzaldehyde, 3-broMo-2-fluoro-4-Methoxy-

Chemical Property:

• Boiling Point: 273.7±35.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.601±0.06 g/cm3(Predicted)
• LogP: 2.40930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-fluoro-4-methoxy-benzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde, 3-broMo-2-fluoro-4-Methoxy-

There total 2 articles about Benzaldehyde, 3-broMo-2-fluoro-4-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Dichloromethyl methyl ether (4885-02-3) + 2‐bromo‐1‐fluoro‐3‐methoxybenzene (446-59-3) → 3-bromo-2-fluoro-4-methoxybenzaldehyde (1155877-70-5)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 0 - 20 ℃; for 2 - 22h; Product distribution / selectivity;

Reference yield:

2‐bromo‐1‐fluoro‐3‐methoxybenzene (446-59-3) + trifluoroacetic acid (76-05-1) → 3-bromo-2-fluoro-4-methoxybenzaldehyde (1155877-70-5)

Guidance literature:

With hexamethylenetetramine; at 90 ℃; for 27h;

Reference yield: 82.0%

3-bromo-2-fluoro-4-methoxybenzaldehyde (1155877-70-5) → (3-bromo-2-fluoro-4-methoxyphenyl)methanol (1155877-71-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 - 20 ℃; for 3.5h;

DOI:10.1016/j.tetlet.2013.03.063

upstream raw materials:

Dichloromethyl methyl ether

2‐bromo‐1‐fluoro‐3‐methoxybenzene

trifluoroacetic acid

Downstream raw materials:

(3-bromo-2-fluoro-4-methoxyphenyl)methanol

2-bromo-4-(bromomethyl)-3-fluoro-1-methoxybenzene

1-(4-(3-bromo-2-fluoro-4-methoxybenzyl)phenyl)urea

1-(4-((3'-chloro-2-fluoro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea