1-Benzyl-4-methylpyrrolidin-3-ol

Base Information

Chemical Name:1-Benzyl-4-methylpyrrolidin-3-ol
CAS No.:143728-93-2
Molecular Formula:C₁₂H₁₇NO
Molecular Weight:191.273
Hs Code.:
DSSTox Substance ID:DTXSID30579830
Mol file:143728-93-2.mol

Synonyms:1-Benzyl-4-methylpyrrolidin-3-ol;143728-93-2;1-Benzyl-4-methyl-pyrrolidin-3-ol;3-Pyrrolidinol, 4-methyl-1-(phenylmethyl)-, trans-(A+/-)-;144124-87-8;TRANS-1-BENZYL-4-METHYL-PYRROLIDIN-3-OL;(3R,4R)-1-benzyl-4-methylpyrrolidin-3-ol;137172-65-7;SCHEMBL501073;DTXSID30579830;NTDFIGIMQABQLD-UHFFFAOYSA-N;1-benzyl-4-methyl-3-pyrrolidinol;137172-63-5;SB33643;1-Benzyl-3-hydroxy-4-methylpyrrolidine;rel-(3S,4R)-1-benzyl-4-methylpyrrolidin-3-ol

Suppliers and Price of 1-Benzyl-4-methylpyrrolidin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
trans-1-Benzyl-4-methyl-pyrrolidin-3-ol
10mg
$ 45.00

American Custom Chemicals Corporation
1-BENZYL-4-METHYL-PYRROLIDIN-3-OL 96.00%
5MG
$ 502.69

Total 2 raw suppliers

Chemical Property of 1-Benzyl-4-methylpyrrolidin-3-ol

Chemical Property:

PSA：23.47000
LogP:1.43710
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:191.131014166
Heavy Atom Count:14
Complexity:177

Purity/Quality:

≥95% ^*data from raw suppliers

trans-1-Benzyl-4-methyl-pyrrolidin-3-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN(CC1O)CC2=CC=CC=C2

Technology Process of 1-Benzyl-4-methylpyrrolidin-3-ol

There total 1 articles about 1-Benzyl-4-methylpyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676-58-4
methylmagnesium chloride

: 75390-09-9
3-benzyl-6-oxa-3-azabicyclo[3.1.0]-hexane

: 137106-06-0,137172-63-5,137172-64-6,137172-65-7,143728-93-2,144124-87-8
trans-N-benzyl-3-hydroxy-4-methylpyrrolidine

Guidance literature:: With copper(II) cyanide; Multistep reaction; 1.) THF, 2.) THF, -20 deg C, 1 h;
DOI:10.1021/jm00100a028

Reference yield:

: 137106-06-0,137172-63-5,137172-64-6,137172-65-7,143728-93-2,144124-87-8
trans-N-benzyl-3-hydroxy-4-methylpyrrolidine

: 137172-67-9
(3R,4S)-N-benzyl-3-azido-4-methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

2: 3.01 g / pyridine / 48 h / 10 °C

3: 0.45 g / NaN₃ / acetonitrile; dimethylformamide / 48 h / Heating

With pyridine; sodium azide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00100a028

Reference yield:

: 137106-06-0,137172-63-5,137172-64-6,137172-65-7,143728-93-2,144124-87-8
trans-N-benzyl-3-hydroxy-4-methylpyrrolidine

: 69498-29-9
(-)-(3R)-N-benzyl-3-methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

2: 2.90 g / NaH / dimethylformamide / 0.5 h / Ambient temperature

3: 0.750 mg / Bu₃SnH, AIBN / toluene / 0.5 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00100a028