(R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate
• CAS No.: 942142-76-9
• Molecular Formula: C₂₁H₃₀ClNO₅
• Molecular Weight: 411.926
• Mol file: 942142-76-9.mol

Synonyms:(R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)Methyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-[(R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl]-, 1,1-dimethylethyl ester, (3R)-

Chemical Property of (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 495.3±25.0 °C(Predicted)
• PKA: -1.91±0.40(Predicted)
• PSA: 65.07000
• Density: 1.171±0.06 g/cm3(Predicted)
• LogP: 4.54580

Purity/Quality:

≥95% ^*data from raw suppliers

(R)-tert-butyl3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate (942142-74-7) + ethyl bromoacetate (105-36-2) → (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate (942142-76-9)

Guidance literature:

(R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

ethyl bromoacetate; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

DOI:10.1021/ml200137x

Reference yield: 40.0%

(3R)-tert-butyl 3-((3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate (942142-70-3) + ethyl bromoacetate (105-36-2) → (3R)-tert-butyl 3-((3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate (942142-71-4,942142-76-9)

Guidance literature:

(3R)-tert-butyl 3-((3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; for 3h; Heating / reflux;

Reference yield:

ethyl bromoacetate (105-36-2) → (R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate (942142-76-9)

Guidance literature:

(R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

ethyl bromoacetate; In tetrahydrofuran; for 3h; Heating / reflux;

ethyl bromoacetate; With sodium hydride; ammonium chloride; more than 3 stages;

upstream raw materials:

ethyl bromoacetate

(R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

(R)-tert-butyl 3-(3-chlorobenzoyl)piperidine-1-carboxylate