ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Base Information

Chemical Name:ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
CAS No.:1310704-15-4
Molecular Formula:C19H29ClN2O2Si
Molecular Weight:380.99
Hs Code.:
Mol file:1310704-15-4.mol

Synonyms:Reaxys ID: 15465536;ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Suppliers and Price of ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
ethyl4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
100mg
$ 414.00

Chemenu
Ethyl4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 95%+
1g
$ 2022.00

Chemenu
Ethyl4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 95%+
250mg
$ 1095.00

Chemenu
Ethyl4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 95%+
100mg
$ 630.00

Total 7 raw suppliers

Chemical Property of ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Chemical Property:

PSA：44.12000
LogP:5.89000

Purity/Quality:

NLT 98% ^*data from raw suppliers

ethyl4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

There total 3 articles about ethyl 4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 541-41-3
chloroformic acid ethyl ester

: 651744-48-8
4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

: 1310704-15-4
ethyl 4-chloro-1-(triisopropylsilyl)-7-azaindole-5-carboxylate

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h;
DOI:10.1016/j.bmcl.2012.11.108

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 55052-28-3
4-chloro-7-azaindole

: 1310704-15-4
ethyl 4-chloro-1-(triisopropylsilyl)-7-azaindole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: sec.-butyllithium / tetrahydrofuran / 1 h / -75 °C

2.2: 1 h / -75 °C

With sec.-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 541-41-3
chloroformic acid ethyl ester

: 1310704-15-4
ethyl 4-chloro-1-(triisopropylsilyl)-7-azaindole-5-carboxylate

Guidance literature:: 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine; With sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

chloroformic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water;