1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-
• CAS No.: 651744-48-8
• Molecular Formula: C16H25ClN2Si
• Molecular Weight: 308.926
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90465942
• Nikkaji Number: J2.021.415E
• Wikidata: Q82292262
• Mol file: 651744-48-8.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 320.543ºC at 760 mmHg
• PKA: 4.34±0.30(Predicted)
• Flash Point: 147.659ºC
• PSA: 17.82000
• Density: 1.058g/cm3
• LogP: 5.71330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 308.1475530
• Heavy Atom Count: 20
• Complexity: 311

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-1-(triisopropylsilyl)-7-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)[Si](C(C)C)(C(C)C)N1C=CC2=C(C=CN=C21)Cl

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]-

There total 3 articles about 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-[tris(1-methylethyl)silyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triisopropylsilyl chloride (13154-24-0) + 4-chloro-7-azaindole (55052-28-3) → 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine (651744-48-8)

Guidance literature:

4-chloro-7-azaindole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

triisopropylsilyl chloride; In tetrahydrofuran; mineral oil; Reflux;

Reference yield:

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) + 4-chloro-7-azaindole (55052-28-3) → 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine (651744-48-8)

Guidance literature:

4-chloro-7-azaindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

triisopropylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

Reference yield:

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine (651744-48-8)

Guidance literature:

4-chloro-7-azaindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

triisopropylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

upstream raw materials:

triisopropylsilyl chloride

4-chloro-7-azaindole

triisopropylsilyl trifluoromethanesulfonate

Downstream raw materials:

4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol

(4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-yl)phenylmethanol

4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde