1-tert-butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate
• CAS No.: 909076-34-2
• Molecular Formula: C₁₄H₂₄ClNO₄
• Molecular Weight: 305.802
• Hs Code.: 2933990090
• Mol file: 909076-34-2.mol

Synonyms:1-tert-butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate;

Chemical Property of 1-tert-butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate

Chemical Property:

• PSA: 55.84000
• LogP: 2.88600

Purity/Quality:

≥95% ^*data from raw suppliers

1-tert-Butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-tert-butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate

There total 3 articles about 1-tert-butyl 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-iodo-3-chloro-propane (6940-76-7) + (S)-N-(tert-butoxycarbonyl)proline methyl ester (59936-29-7) → 1-(tert-butyl) 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate (909076-34-2)

Guidance literature:

(S)-N-(tert-butoxycarbonyl)proline methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 2h;

1-iodo-3-chloro-propane; In tetrahydrofuran; at -70 - 20 ℃;

Reference yield: 60.0%

(+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2) + 1.3-chlorobromopropane (109-70-6) → 1-(tert-butyl) 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate (909076-34-2)

Guidance literature:

(+/-)-N-tert-butoxycarbonylproline methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -65 ℃; for 1h;

1.3-chlorobromopropane; In tetrahydrofuran; at -65 - 20 ℃; for 2h;

Reference yield:

1-iodo-3-chloro-propane (6940-76-7) + (+/-)-N-tert-butoxycarbonylproline methyl ester (145681-01-2) → 1-(tert-butyl) 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate (909076-34-2)

Guidance literature:

(+/-)-N-tert-butoxycarbonylproline methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

1-iodo-3-chloro-propane; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

upstream raw materials:

1-iodo-3-chloro-propane

(S)-N-(tert-butoxycarbonyl)proline methyl ester

(+/-)-N-tert-butoxycarbonylproline methyl ester

1.3-chlorobromopropane

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