BenzeneMethanol, 3-[(1R)-3-[bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-(phenylMethoxy)-

Base Information

• Chemical Name: BenzeneMethanol, 3-[(1R)-3-[bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-(phenylMethoxy)-
• CAS No.: 156755-37-2
• Molecular Formula: C29H37NO2
• Molecular Weight: 431.618
• Mol file: 156755-37-2.mol

Synonyms:(R)-(4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)phenyl)methanol;O-Des(2-Methylpropan-1-one)-O-Benzyl-Fesoteridone;

Chemical Property of BenzeneMethanol, 3-[(1R)-3-[bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-(phenylMethoxy)-

Chemical Property:

• PSA: 32.70000
• LogP: 6.39870

Purity/Quality:

97% ^*data from raw suppliers

O-Des(2-Methylpropan-1-one)-O-Benzyl-Fesoteridone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: O-Des(2-Methylpropan-1-one)-O-Benzyl-Fesoteridone is an impurity in the synthesis of Fesoteridone (F321300), a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS).

Technology Process of BenzeneMethanol, 3-[(1R)-3-[bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-(phenylMethoxy)-

There total 44 articles about BenzeneMethanol, 3-[(1R)-3-[bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-(phenylMethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate (156755-35-0) → {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol (156755-37-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 20h;

Reference yield:

(R)-4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)benzoic acid hydrochloride (156755-33-8) → {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol (156755-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 10 °C / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 25 - 30 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran;

Reference yield:

(R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal (214601-54-4) → {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol (156755-37-2)

Guidance literature:

With sodium tetrahydroborate; water; sodium hydroxide; In acetonitrile; at 25 - 30 ℃; for 3.66667h; Concentration; Reagent/catalyst; Temperature; Time; Large scale;

upstream raw materials:

methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate

formaldehyd

R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

(E)-3-phenylacrylic acid

Downstream raw materials:

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

fesoterodine

fesoterodine fumarate

fesoterodine fumarate