Benzoic acid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-, hydrochloride

Base Information

Chemical Name:Benzoic acid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-, hydrochloride
CAS No.:156755-33-8
Molecular Formula:C29H36ClNO3
Molecular Weight:482.063
Hs Code.:
Mol file:156755-33-8.mol

Synonyms:(3R)-4-benzyl-5-oxomorpholin-3-carboxylic acid;(R)-4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-benzoic acid hydrochloride;(3R)-5-oxo-4-phenylmethyl-3-morpholinecarboxylic acid;(3R)-4-benzyl-5-oxo-morpholine-3-carboxylic acid;(R)-4-benzyl-5-oxomorpholine-3-carboxylic acid;(R)-4-Benzyl-5-oxo-3-morpholinecarboxylic Acid;

Suppliers and Price of Benzoic acid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-, hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
Benzoicacid,3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-,(Hydrochloride)9CI
1g
$ 495.00

Total 7 raw suppliers

Chemical Property of Benzoic acid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-, hydrochloride

Chemical Property:

PSA：49.77000
LogP:7.40660

Purity/Quality:

97% ^*data from raw suppliers

Benzoicacid,3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-,(Hydrochloride)9CI ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-, hydrochloride

There total 14 articles about Benzoic acid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-96-4
ethyl bromide

: 950773-38-3
R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

: 156755-33-8
(R)-4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)benzoic acid hydrochloride

Guidance literature:: ethyl bromide; R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine; With magnesium; iodine; In tetrahydrofuran; at -70 - 70 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; at -5 - 35 ℃;

With hydrogenchloride; In water; pH=1 - 2;

Reference yield:

: 950773-38-3
R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

: 124-38-9,18923-20-1
carbon dioxide

: 156755-33-8
(R)-4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)benzoic acid hydrochloride

Guidance literature:: R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine; With ethyl bromide; iodine; magnesium; In tetrahydrofuran; at 55 - 60 ℃;

carbon dioxide; In tetrahydrofuran; at -65 - -60 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: (R)-3-(2-(benzyloxy)-5-bromophenyl)-N,N-diisopropyl-3-phenylpropan-1-amine, D-tartrate salt

: 156755-33-8
(R)-4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)benzoic acid hydrochloride

Guidance literature:: (R)-3-(2-(benzyloxy)-5-bromophenyl)-N,N-diisopropyl-3-phenylpropan-1-amine, D-tartrate salt; With water; sodium hydroxide; In dichloromethane; at 10 - 20 ℃; for 0.25h; pH=11.5;

With ethyl bromide; iodine; magnesium; In tetrahydrofuran; at 25 - 55 ℃; for 4h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at -70 - -10 ℃; Inert atmosphere;