(R)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate

Base Information

• Chemical Name: (R)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate
• CAS No.: 1234474-58-8
• Molecular Formula: C11H12O4
• Molecular Weight: 208.21
• Mol file: 1234474-58-8.mol

Synonyms:(R)-Methyl 6-Hydroxy-2,3-dihydrobenzofuran-3-ylacetat e;(R)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate;(R)-Methyl 6-Hydroxy-2,3-dihydrobenzofuran-3-ylacetat e,99%e.e.;3-?Benzofuranacetic acid, 2,?3-?dihydro-?6-?hydroxy-?, methyl ester, (3R)?-

Chemical Property of (R)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate

Chemical Property:

• PSA: 55.76000
• LogP: 1.43130

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate

There total 30 articles about (R)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (726174-52-3) → methyl ((3S)-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetate (1000414-38-9,1234474-58-8)

Guidance literature:

With hydrogen; C₃₉H₃₆IrNOP⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); In dichloromethane; at 25 ℃; for 24h; under 38002.6 Torr; enantioselective reaction; Autoclave; Glovebox;

DOI:10.1002/chem.202002532

Reference yield: 95.5%

(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (726174-52-3) → (6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (805250-17-3,1234474-58-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h;

Reference yield: 93.0%

methanol (67-56-1) + 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetic acid (1000414-37-8) → (6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (805250-17-3,1234474-58-8)

Guidance literature:

With thionyl chloride; at 20 ℃; for 2.16667h; Cooling with ice;

upstream raw materials:

6-methoxy-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran

(6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester

4-chloromethyl-7-hydroxycoumarin

recorcinol

Downstream raw materials:

{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]-2,3-dihydro-benzofuran-3-yl}acetic acid

methyl [(3R)-6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

[(3R)-6-({2',6'-dimethyl-4'-[(3-methyloxetan-3-yl)methoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

methyl [(3R)-6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-2,3-dihydro-1-benzofuran-3-yl]acetate

Refernces

• 1、 Ge, Yao,Wang, Zheng,Han, Zhaobin,Ding, Kuiling. "Iridium-Catalyzed Enantioselective Hydrogenation of Indole and Benzofuran Derivatives". supporting information. p. 15482 - 15486. Retrieved 2020/07/30.
• 2、 Li, Zheng,Hu, Lijun,Wang, Xuekun,Zhou, Zongtao,Deng, Liming,Xu, Yawen,Zhang, Luyong. "Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents". . . Retrieved 2019/09/12.