(2S)-2-((1R,3aR,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

Base Information

Chemical Name:(2S)-2-((1R,3aR,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol
CAS No.:215509-33-4
Molecular Formula:C19H38O2Si
Molecular Weight:326.59
Hs Code.:
Mol file:215509-33-4.mol

Synonyms:(2S)-2-((1R,3aR,7aR)-4-((tert-butyldiMethylsilyl)oxy)-7a-Methyloctahydro-1H-inden-1-yl)propan-1-ol;1H-Indene-1-ethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-β,7a-dimethyl-, (βS,1R,3aR,7aR)-;(2S)-2-[(1R,3aR,7aR)-4-[tert-butyl(dimethyl)silyl]oxy-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-1-yl]propan-1-ol

Suppliers and Price of (2S)-2-((1R,3aR,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-((1R,3aR,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

Chemical Property:

Boiling Point:367.3±15.0 °C(Predicted)
PKA:14.98±0.10(Predicted)
Density:0.94±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (2S)-2-((1R,3aR,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

There total 53 articles about (2S)-2-((1R,3aR,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 189102-76-9
de-A,B-8β,22-di-[(tert-butyldimethyl)silyloxy]-23,24-dinorcholane

: 100928-03-8,215509-33-4
(S)-2-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 96.0%

: 64190-52-9
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 100928-03-8,215509-33-4
(S)-2-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

Guidance literature:: (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol; tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 60 ℃; for 48h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ol060231w

Reference yield: 95.0%

: 502687-69-6
des-A,B-22,23-dinor-8β-[(tert-butyldimethylsilyl)oxy]chol-16-en-22-ol

: 100928-03-8,215509-33-4
(S)-2-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 24h; under 760.051 Torr; diastereoselective reaction;
DOI:10.1021/acs.orglett.5b03138