2-Acetamido-4-methyl-5-bromopyridine

Base Information

• Chemical Name: 2-Acetamido-4-methyl-5-bromopyridine
• CAS No.: 142404-82-8
• Molecular Formula: C8H9BrN2O
• Molecular Weight: 229.076
• Hs Code.: 29333990
• Mol file: 142404-82-8.mol

Synonyms:2-Acetylamino-5-bromo-4-methylpyridine;2-Acetamido-5-bromo-4-picoline;N-(5-Bromo-4-methyl-pyridin-2-yl)-acetamide;2-Acetamido-5-bromo-gamma-picoline;

Chemical Property of 2-Acetamido-4-methyl-5-bromopyridine

Chemical Property:

• Vapor Pressure: 9.6E-06mmHg at 25°C
• Melting Point: 151-155 °C(lit.)
• Refractive Index: 1.606
• Boiling Point: 372.5 °C at 760 mmHg
• PKA: 12.94±0.70(Predicted)
• Flash Point: 179.1 °C
• PSA: 41.99000
• Density: 1.545 g/cm³
• LogP: 2.18390
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Chloroform

Purity/Quality:

98%min ^*data from raw suppliers

2-Acetamido-5-bromo-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-42/43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Acetamido-5-bromo-4-methylpyridine is used in the continuous exothermix process of nitration.

Technology Process of 2-Acetamido-4-methyl-5-bromopyridine

There total 6 articles about 2-Acetamido-4-methyl-5-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-acetylamino-4-methylpyridine (5327-32-2) → 2-acetamido-4-methylpyridinium hydrobromide perbromide + N-(5-bromo-4-methylpyridin-2-yl)acetamide (142404-82-8)

Guidance literature:

With bromine; In dichloromethane;

Reference yield: 83.0%

5-bromo-2-fluoro-4-methyl-pyridine (864830-16-0) + acetamidine hydrochloride (124-42-5) → N-(5-bromo-4-methylpyridin-2-yl)acetamide (142404-82-8)

Guidance literature:

With water; caesium carbonate; In dimethyl sulfoxide; at 90 ℃; for 18h; chemoselective reaction; Schlenk technique;

DOI:10.1039/d0ob01904f

Reference yield: 82.0%

2-acetylamino-4-methylpyridine (5327-32-2) → N-(5-bromo-4-methylpyridin-2-yl)acetamide (142404-82-8)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

upstream raw materials:

2-amino-5-bromo-4-methylpyridine

acetic anhydride

2-acetylamino-4-methylpyridine

2-Amino-4-methylpyridine

Downstream raw materials:

6-acetamido-4-methylpyridin-3-ylboronic acid

2-amino-3-nitro-4-methyl-5-bromopyridine

1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl hydrogen phosphate

C₂₅H₂₄ClN₇O₄

Refernces

• 1、 Chen, Lu,Huang, Shuo,Ji, Xiaoliang,Li, Jiaming,Li, Jian,Li, Yibiao,Liu, Jiasheng,Peng, Shiyong,Zhang, Kun. "Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride". supporting information. p. 9292 - 9299. Retrieved 2020/12/03.
• 2、 -. "SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS". Page/Page column 79. . Retrieved 2012/02/02.