Chemical Property of 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Chemical Property:
- Boiling Point:483.0±45.0 °C(Predicted)
- PKA:-3.45±0.20(Predicted)
- PSA：49.85000
- Density:1.61
- LogP:2.65210
- Storage Temp.:-196°C
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:3.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:359.983525
- Heavy Atom Count:22
- Complexity:520
- Purity/Quality:
-
99%, *data from raw suppliers
RI1 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl
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Description
RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
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Uses
RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells.
