2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester

Base Information

• Chemical Name: 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
• CAS No.: 36745-93-4
• Molecular Formula: C7H6Cl2N2O2
• Molecular Weight: 221.043
• Hs Code.: 2933599090
• Mol file: 36745-93-4.mol

Synonyms:2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester;Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate

Chemical Property of 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester

Chemical Property:

• Boiling Point: 292℃
• PKA: -3.83±0.39(Predicted)
• Flash Point: 131℃
• PSA: 52.08000
• Density: 1.435
• LogP: 1.87840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2,4-dichloro-6-methylpyrimidine-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic Acid Methyl Ester is used in preparation of 4,6,7-Trisubstituted 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3 -one derivatives useful as Btk kinase inhibitors.

Technology Process of 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester

There total 6 articles about 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methyl-2,6-dioxo-3H-pyrimidine-5-carboxylic acid methyl ester (869891-41-8) → 2,4-dichloro-6-methyl-pyrimidine-5-carboxylic acid methyl ester (36745-93-4)

Guidance literature:

With trichlorophosphate; N,N-dimethyl-aniline; at 105 ℃; for 6h;

Reference yield:

methyl 3-aminocrotonate (14205-39-1) → 2,4-dichloro-6-methyl-pyrimidine-5-carboxylic acid methyl ester (36745-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 4 h / 0 - 5 °C

2: triethylamine / water / 21 h / 50 - 60 °C

3: tributyl-amine; trichlorophosphate / 3 h / 95 °C

With tributyl-amine; triethylamine; trichlorophosphate; In diethyl ether; water;

Reference yield:

3-amino-2-(ethoxycarbonyl-carbamoyl)-but-2-enoic acid methyl ester (936020-16-5) → 2,4-dichloro-6-methyl-pyrimidine-5-carboxylic acid methyl ester (36745-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / water / 21 h / 50 - 60 °C

2: tributyl-amine; trichlorophosphate / 3 h / 95 °C

With tributyl-amine; triethylamine; trichlorophosphate; In water;

upstream raw materials:

4-methyl-2,6-dioxo-3H-pyrimidine-5-carboxylic acid methyl ester

methyl 3-aminocrotonate

3-amino-2-(ethoxycarbonyl-carbamoyl)-but-2-enoic acid methyl ester

Downstream raw materials:

methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate

2-((1R,2S)-2-aminocyclohexylamino)-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one

methyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate

tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate