UNC0638

Base Information

Chemical Name:UNC0638
CAS No.:1255580-76-7
Molecular Formula:C30H47N5O2
Molecular Weight:509.735
Hs Code.:
Mol file:1255580-76-7.mol

Synonyms:UNC 0638;UNII-26A103L2FO;

Suppliers and Price of UNC0638

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
5mg
$ 100.00

Tocris
UNC0638 ≥98%(HPLC)
10
$ 255.00

DC Chemicals
UNC-0638 >98%
250 mg
$ 850.00

DC Chemicals
UNC-0638 >98%
100 mg
$ 450.00

Crysdot
UNC0638 98+%
50mg
$ 370.00

Crysdot
UNC0638 98+%
100mg
$ 665.00

ChemScene
UNC0638 99.73%
50mg
$ 300.00

ChemScene
UNC0638 99.73%
10mg
$ 108.00

ChemScene
UNC0638 99.73%
5mg
$ 72.00

ChemScene
UNC0638 99.73%
100mg
$ 528.00

Total 32 raw suppliers

Chemical Property of UNC0638

Chemical Property:

Melting Point:93-94℃
Boiling Point:610.2±55.0 °C(Predicted)
PKA:10.07±0.20(Predicted)
PSA：62.75000
Density:1.124±0.06 g/cm3(Predicted)
LogP:5.78430
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Solubility.:≥25.5 mg/mL in DMSO; insoluble in H2O; ≥48.2 mg/mL in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine, is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP.

Technology Process of UNC0638

There total 9 articles about UNC0638 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19748-66-4
3-pyrrolidin-1-yl-propan-1-ol

: 1320288-42-3
C₂₃H₃₄N₄O₂

: 1255580-76-7
2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200903z

Reference yield:

: 385784-84-9
4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile

: 1255580-76-7
2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Guidance literature:: Multi-step reaction with 7 steps

1: water; iron; ammonium chloride / isopropyl alcohol / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

3: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

6: palladium 10% on activated carbon; cyclohexa-1,4-diene / ethanol / 2 h / Reflux

7: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; dihydrogen peroxide; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 7: Mitsunobu reaction;
DOI:10.1021/jm200903z

Reference yield:

: 385785-02-4
2-amino-4-(benzyloxy)-5-methoxybenzonitrile

: 1255580-76-7
2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

5: palladium 10% on activated carbon; cyclohexa-1,4-diene / ethanol / 2 h / Reflux

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With cyclohexa-1,4-diene; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 6: Mitsunobu reaction;
DOI:10.1021/jm200903z