Degarelix Acetate

Base Information

Chemical Name:Degarelix Acetate
CAS No.:934016-19-0
Molecular Formula:C₂H₄O₂*C₈₂H₁₀₃ClN₁₈O₁₆
Molecular Weight:1692.34
Hs Code.:
European Community (EC) Number:807-570-7
UNII:EXT215F4ZU
ChEMBL ID:CHEMBL2028987
DSSTox Substance ID:DTXSID201027699
NCI Thesaurus Code:C80443
Wikidata:Q27277419

Synonyms:Ac-2Nal-4Cpa-3Pal-Ser-4Aph(hydroorotyl)-4Aph(carbamoyl)-Leu-ILys-pro-Ala-NH2;acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide;degarelix;degarelix acetate;FE 200486;FE-200486;FE200486;Firmagon;Gonax;uglypeptide1

Suppliers and Price of Degarelix Acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of Degarelix Acetate

Chemical Property:

Hydrogen Bond Donor Count:18
Hydrogen Bond Acceptor Count:20
Rotatable Bond Count:41
Exact Mass:1690.7699263
Heavy Atom Count:121
Complexity:3420

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)NC(=O)N)NC(=O)C(CC3=CC=C(C=C3)NC(=O)C4CC(=O)NC(=O)N4)NC(=O)C(CO)NC(=O)C(CC5=CN=CC=C5)NC(=O)C(CC6=CC=C(C=C6)Cl)NC(=O)C(CC7=CC8=CC=CC=C8C=C7)NC(=O)C.CC(=O)O
Isomeric SMILES:C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CC=C(C=C2)NC(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)NC(=O)[C@@H]4CC(=O)NC(=O)N4)NC(=O)[C@H](CO)NC(=O)[C@@H](CC5=CN=CC=C5)NC(=O)[C@@H](CC6=CC=C(C=C6)Cl)NC(=O)[C@@H](CC7=CC8=CC=CC=C8C=C7)NC(=O)C.CC(=O)O
Recent ClinicalTrials:Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular Tracers
Recent EU Clinical Trials:PREFAcE : Interest of PET-PSMA imaging potentiated by androgen blockade in patients with biological relapse or persistent biological disease of a localized prostatic adenocarcinoma after initial treatment

Technology Process of Degarelix Acetate

There total 1 articles about Degarelix Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35661-60-0
Fmoc-Leu-OH

: 201003-48-7
Fmoc-L-Lys(iPr,Boc)-OH

: 9-fluorenylmethyloxycarbonyl-N⁽⁴⁾-(L-hydroorotyl)-4-aminophenylalanine

: 9-fluorenylmethyloxycarbonyl-N⁽⁴⁾-(t-butylcarbamoyl)-D-4-aminophenylalanine

: 71989-31-6
Fmoc-Pro-OH

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 9-fluorenylmethyloxycarbonyl-D-2-naphthylalanine

: 108-24-7
acetic anhydride

: 35661-38-2,35661-39-3,79990-15-1,136132-75-7
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 9-fluorenylmethyloxycarbonyl-D-4-chlorophenylalanine

: 175453-07-3,142994-45-4
(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid

: 934016-19-0
(4S)‐N‐(4‐((2S,5S,8R,11R)‐2‐(((R)‐1‐(((S)‐1‐(((S)‐1‐((S)‐2‐(((R)‐1‐amino‐1‐oxopropan‐2‐yl)carbamoyl)pyrrolidin‐1‐yl)‐6‐(isopropylamino)‐1‐oxohexan‐2‐yl)amino)‐4‐methyl‐1‐oxopentan‐2‐yl)amino)‐1‐oxo‐3‐(4‐ureidophenyl)propan‐2‐yl)carbamoyl)‐11‐(4‐chlorobenzyl)‐5‐(hydroxymethyl)‐14‐((naphthalen‐2‐yl)methyl)‐4,7,10,13,16‐pentaoxo‐8‐(pyridin‐3‐ylmethyl)‐3,6,9,12,15‐pentaazaheptadecyl)phenyl)‐2,6‐dioxohexahydropyrimidine‐4‐carboxamide acetate

Guidance literature:: N-(9-fluorenylmethoxycarbonyl)-D-alanine; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 10 ℃; for 2h;

With 3-azapentane-1,5-diamine; In N,N-dimethyl-formamide; for 0.5h;

Fmoc-Leu-OH; Fmoc-L-Lys(iPr,Boc)-OH; 9-fluorenylmethyloxycarbonyl-N⁽⁴⁾-(L-hydroorotyl)-4-aminophenylalanine; 9-fluorenylmethyloxycarbonyl-N⁽⁴⁾-(t-butylcarbamoyl)-D-4-aminophenylalanine; Fmoc-Pro-OH; Fmoc-Ser(tBu)-OH; 9-fluorenylmethyloxycarbonyl-D-2-naphthylalanine; acetic anhydride; 9-fluorenylmethyloxycarbonyl-D-4-chlorophenylalanine; (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid; Further stages;