2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-, sodium salt (1:1)

Base Information

• Chemical Name: 2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-, sodium salt (1:1)
• CAS No.: 1237524-82-1
• Molecular Formula: C5H5N3NaO2*
• Molecular Weight: 161.095
• Mol file: 1237524-82-1.mol

Synonyms:2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-, sodium salt (1:1);

Chemical Property of 2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-, sodium salt (1:1)

Chemical Property:

• PSA: 91.93000
• LogP: 0.41960

Purity/Quality:

99% ^*data from raw suppliers

Sodium(3-oxo-3,4-dihydropyrazine-2-carbonyl)amide ≥98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-, sodium salt (1:1)

There total 1 articles about 2-Pyrazinecarboxamide, 3,4-dihydro-3-oxo-, sodium salt (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Glyoxal (131543-46-9,107-22-2) + 2-aminopropanediamide (62009-47-6) → 3-hydroxy-2-carbamoylpyrazine sodium salt (1237524-82-1)

Guidance literature:

With sodium hydroxide; In water; at -10 - 22 ℃; for 4.66667h;

Reference yield: 65.0%

3-hydroxy-2-carbamoylpyrazine sodium salt (1237524-82-1) → favipiravir (259793-96-9)

Guidance literature:

With pyridine; sodium nitrate; 6,6'-dimethoxy-2,2'-bipyridine; toluene-4-sulfonic acid; silver nitrate; Selectfluor; In acetonitrile; at 75 ℃; for 12h; Reagent/catalyst; Temperature;

upstream raw materials:

Glyoxal

2-aminopropanediamide

Downstream raw materials:

favipiravir

Refernces

• 1、 Charoensetakul, Netnapa,Khamkhenshorngphanuch, Thitiphong,Srikun, Onsiri,Srimongkolpithak, Nitipol,Thongpanchang, Chawanee,Tiyasakulchai, Thanat,Yuthavong, Yongyuth. "Scalable synthesis of favipiravir: Via conventional and continuous flow chemistry". . p. 38691 - 38693. Retrieved 2021/12/20.
• 2、 -. "METHOD FOR PRODUCING DICHLOROPYRAZINE DERIVATIVE". Page/Page column 4-5. . Retrieved 2011/11/13.