(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

Base Information

Chemical Name:(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol
CAS No.:1241914-87-3
Molecular Formula:C19H16FN5O
Molecular Weight:349.367
Hs Code.:
Mol file:1241914-87-3.mol

Synonyms:(4-fluorophenyl)(2-hydroxyphenyl)methanone;(2-hydroxyphenyl)(4-fluorophenyl)methanone;(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol;Methanone,(4-fluorophenyl)(2-hydroxyphenyl);

Suppliers and Price of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

Chemical Property:

Boiling Point:528.8±50.0 °C(Predicted)
PKA:12.61±0.20(Predicted)
PSA：89.95000
Density:1.421±0.06 g/cm3(Predicted)
LogP:3.04760

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol

There total 7 articles about (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1241914-71-5
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone

: 1241914-87-3
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanol

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1.5h;

Reference yield: 30.0%

: 1241914-71-5
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone

: (4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone

: 1241914-87-3
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1241914-87-3
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran

2: DIEA / N,N-dimethyl-formamide; water

3: sodium tetrahydroborate / tetrahydrofuran; methanol

With hydrogenchloride; sodium tetrahydroborate; DIEA; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;