AM095

Base Information

• Chemical Name: AM095
• CAS No.: 1228690-36-5
• Molecular Formula: C27H24N2O5
• Molecular Weight: 456.48986
• Hs Code.: 2934999090
• Mol file: 1228690-36-5.mol

Synonyms:AM 095;AM095;

Chemical Property of AM095

Chemical Property:

• Boiling Point: 641.9±55.0 °C(Predicted)
• PKA: 4.21±0.10(Predicted)
• PSA: 105.15000
• Density: 1.278±0.06 g/cm3(Predicted)
• LogP: 6.26740
• Solubility.: insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic

Purity/Quality:

97% ^*data from raw suppliers

AM095freeacid >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AM095

There total 9 articles about AM095 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid ethyl ester (1228690-38-7) → AM095 (1228690-36-5)

Guidance literature:

{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid ethyl ester; With water; lithium hydroxide; In methanol; at 20 ℃;

In methanol; water; Acidic conditions;

Reference yield:

(R)-1-phenylethanol (1517-69-7) → AM095 (1228690-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C

2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

3: water; lithium hydroxide / methanol / 20 °C

With diphenyl phosphoryl azide; water; sodium hydrogencarbonate; triethylamine; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1,2-dimethoxyethane; water; toluene; 2: Suzuki Coupling;

Reference yield:

acetophenone (98-86-2) → AM095 (1228690-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylsulfide borane complex; (3aS)-1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydro-2H-pyrrolo[2,1-e]azaborole / tetrahydrofuran / 0.25 h / 0 - 20 °C

2: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C

3: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

4: water; lithium hydroxide / methanol / 20 °C

With dimethylsulfide borane complex; (3aS)-1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydro-2H-pyrrolo[2,1-e]azaborole; diphenyl phosphoryl azide; water; sodium hydrogencarbonate; triethylamine; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; toluene; 3: Suzuki Coupling;

upstream raw materials:

{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetic acid ethyl ester

acetophenone

Ethyl 4-bromophenylacetate

(R)-1-phenylethanol

Downstream raw materials:

(2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid) sodium salt