(R)-2-(Aminomethyl)-4-methylpentanoic acid

Base Information

• Chemical Name: (R)-2-(Aminomethyl)-4-methylpentanoic acid
• CAS No.: 210345-89-4
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.2
• DSSTox Substance ID: DTXSID40463251
• Nikkaji Number: J860.185B
• Wikidata: Q27454797
• Mol file: 210345-89-4.mol

Synonyms:(R)-2-(Aminomethyl)-4-methylpentanoic acid;210345-89-4;(2R)-2-(AMINOMETHYL)-4-METHYLPENTANOIC ACID;Pentanoic acid, 2-(aminomethyl)-4-methyl-, (2R)-;MFCD07372885;(R)-2-AMINOMETHYL-4-METHYL-PENTANOIC ACID;(R)-2-(Aminomethyl)-4-methylpentanoicacid;SCHEMBL4738612;DTXSID40463251;AKOS016844034;DS-5570;A879294;Q27454797

Chemical Property of (R)-2-(Aminomethyl)-4-methylpentanoic acid

Chemical Property:

• PSA: 63.32000
• LogP: 1.39230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 145.110278721
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(Aminomethyl)-4-methylpentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(CN)C(=O)O
• Isomeric SMILES: CC(C)C[C@H](CN)C(=O)O

Technology Process of (R)-2-(Aminomethyl)-4-methylpentanoic acid

There total 26 articles about (R)-2-(Aminomethyl)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2R)-([{(benzyloxy)carbonyl}amino]methyl)-4-methylpentanoic acid (132606-01-0) → (2R)-([amino]methyl)-4-methylpentanoic acid (210345-89-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 4h; under 760.051 Torr; enantioselective reaction;

DOI:10.1016/j.tetasy.2008.12.023

Reference yield: 86.0%

(R)-2-(Benzoylamino-methyl)-4-methyl-pentanoic acid (210345-88-3) → (2R)-([amino]methyl)-4-methylpentanoic acid (210345-89-4)

Guidance literature:

With hydrogenchloride; In acetic acid; at 110 ℃;

DOI:10.1039/b106368p

Reference yield:

(2S)-([{(benzyloxy)carbonyl}amino]methyl)-4-methylpentanoic acid (631899-15-5) → (2R)-([amino]methyl)-4-methylpentanoic acid (210345-89-4) + (2S)-([amino]methyl)-4-methylpentanoic acid (203854-56-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 4h; under 760.051 Torr; enantioselective reaction;

DOI:10.1016/j.tetasy.2008.12.023

upstream raw materials:

N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

(R)-2-(Benzoylamino-methyl)-4-methyl-pentanoic acid

(R)-2-(((benzyloxy)amino)methyl)-4-methylpentanoic acid

(4R)-isobutyl-2-((S)-1-phenylethyl)-isoxazolidin-5-one

Downstream raw materials:

2-(R)-(N-boc-aminomethyl) 4-methyl-pentanoic acid

Boc-(R)-β²-HVal-(R)-β²-HAla-(R)-β²-HLeu-(2R,3R)-β^2,3-HAla(α-Me)-(R)-β²-HVal-(R)-β²-HAla-(R)-β²-HLeu-OBn

(R)-2-[((R)-3-{(R)-2-[((2R,3R)-3-tert-Butoxycarbonylamino-2-methyl-butyrylamino)-methyl]-3-methyl-butyrylamino}-2-methyl-propionylamino)-methyl]-4-methyl-pentanoic acid benzyl ester

C₄₆H₇₈N₆O₉