N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

Base Information

Chemical Name:N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide
CAS No.:191664-13-8
Molecular Formula:C₂₄H₂₈N₂O₄
Molecular Weight:408.497
Hs Code.:

Synonyms:N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

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Technology Process of N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

There total 1 articles about N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 38792-42-6
N-(chloromethyl)benzamide

: 113543-30-9
(S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one

: 191664-13-8
N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

Guidance literature:: With titanium tetrachloride; triethylamine; In dichloromethane; at 0 ℃; for 60h;
DOI:10.1002/hlca.19980810513

Reference yield: 76.0%

: 191664-13-8
N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

: 210345-88-3
(R)-2-(Benzoylamino-methyl)-4-methyl-pentanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 1h;
DOI:10.1002/hlca.19980810513

Reference yield:

: 191664-13-8
N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-pentyl]-benzamide

: 191664-19-4
C₄₆H₇₈N₆O₉

Guidance literature:: Multi-step reaction with 8 steps

1: 76 percent / H₂O₂, LiOH*H₂O / H₂O; tetrahydrofuran / 1 h / 0 °C

2: 65 percent / aq. HCl / acetic acid / 48 h / Heating

3: 86 percent / benzene / 9 h / Heating

4: 91 percent / 1-hydroxy-1H-benzotriazole, N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide / tetrahydrofuran / 1h, 0 deg C; 18 h, r.t.

5: HCl / dioxane / 2 h / 20 °C

6: 74 percent / 1-hydroxy-1H-benzotriazole, N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide / tetrahydrofuran / 1h, 0 deg C; 18 h, r.t.

7: 99 percent / H₂ / Pd/C / methanol / 18 h

8: 69 percent / 1-hydroxy-1H-benzotriazole, N-methylmorpholine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide / tetrahydrofuran / 1h, 0 deg C; 18 h, r.t.

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid; benzene;
DOI:10.1002/hlca.19980810513