Methyl 2-Amino-3-bromopyrazine-5-carboxylate

Base Information

• Chemical Name: Methyl 2-Amino-3-bromopyrazine-5-carboxylate
• CAS No.: 1076198-49-6
• Molecular Formula: C6H6BrN3O2
• Molecular Weight: 232.037
• Hs Code.: 2933990090
• Mol file: 1076198-49-6.mol

Synonyms:5-AMino-6-broMo-2-pyrazinecarboxylic acid Methyl ester;;Methyl 5-aMino-6-broMo-2-pyrazinecarboxylate;5-AMino-6-broMo-;

Chemical Property of Methyl 2-Amino-3-bromopyrazine-5-carboxylate

Chemical Property:

• Melting Point: 173-175°C
• Boiling Point: 378.3±37.0 °C(Predicted)
• PKA: -0.79±0.10(Predicted)
• PSA: 78.10000
• Density: 1.754±0.06 g/cm3(Predicted)
• LogP: 1.18910
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Amino-3-bromopyrazine-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Amino-3-bromopyrazine-5-carboxylate (cas# 1076198-49-6) is a compound useful in organic synthesis.

Technology Process of Methyl 2-Amino-3-bromopyrazine-5-carboxylate

There total 1 articles about Methyl 2-Amino-3-bromopyrazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-amino-pyrazine-2-carboxylic acid methyl ester (13924-94-2) → methyl 5-amino-6-bromopyrazine-2-carboxylate (1076198-49-6)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 2h;

Reference yield: 50.0%

methyl 5-amino-6-bromopyrazine-2-carboxylate (1076198-49-6) + [3-(benzyloxy)-4-chlorophenyl]boronic acid (1007170-24-2) → methyl 5-amino-6-[3-(benzyloxy)-4-chlorophenyl]pyrazine-2-carboxylate

Guidance literature:

With sodium carbonate; bis(benzonitrile)palladium(II) dichloride; n-butyl-diphenylphosphane; In ethanol; water; toluene; for 5.5h; Inert atmosphere; Reflux;

Reference yield:

methyl 5-amino-6-bromopyrazine-2-carboxylate (1076198-49-6) → ethyl 8-(4[2-[(3R)-3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl]ethynyl]phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 150 °C / Microwave irradiation; Sealed tube

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 80 °C / Sealed tube; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In acetonitrile; 2: |Suzuki Coupling;

upstream raw materials:

5-amino-pyrazine-2-carboxylic acid methyl ester

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