Methyl 5-aminopyrazine-2-carboxylate

Base Information

• Chemical Name: Methyl 5-aminopyrazine-2-carboxylate
• CAS No.: 13924-94-2
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• Hs Code.: 2933990090
• European Community (EC) Number: 818-541-3
• DSSTox Substance ID: DTXSID90561413
• Nikkaji Number: J81.694I
• Wikidata: Q72441408
• Mol file: 13924-94-2.mol

Synonyms:METHYL 5-AMINOPYRAZINE-2-CARBOXYLATE;13924-94-2;5-Aminopyrazine-2-carboxylic acid methyl ester;2-Aminopyrazine-5-carboxylic Acid Methyl Ester;Methyl 2-amino-5-pyrazinecarboxylate;5-AMINO-PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;2-Pyrazinecarboxylic acid, 5-amino-, methyl ester;MFCD09753440;Methyl5-Aminopyrazine-2-carboxylate;SCHEMBL544241;DTXSID90561413;RPEZSZAVQOVHCZ-UHFFFAOYSA-N;BCP21919;AKOS006329236;CS-W003640;PB12687;SB10299;AC-28841;AM803194;DS-16268;SY006678;EN300-131101;A807503;W-205527;Z1198223353;5-Amino-pyrazine-2-carboxylic acid methyl ester hydrochloride;Methyl 5-aminopyrazine-2-carboxylate pound>>2-Aminopyrazine-5-carboxylic Acid Methyl Ester pound>>Methyl 2-amino-5-pyrazinecarboxylate

Chemical Property of Methyl 5-aminopyrazine-2-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 230-232?C
• Refractive Index: 1.577
• Boiling Point: 363.035 °C at 760 mmHg
• Flash Point: 173.358 °C
• PSA: 78.10000
• Density: 1.32 g/cm³
• LogP: 1.22860
• Storage Temp.: -20°C Freezer
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 153.053826475
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

97% ^*data from raw suppliers

2-Aminopyrazine-5-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=CN=C(C=N1)N

Technology Process of Methyl 5-aminopyrazine-2-carboxylate

There total 6 articles about Methyl 5-aminopyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-fluoro-pyrazine-2-carboxylic acid methyl ester (169335-35-7) → 5-amino-pyrazine-2-carboxylic acid methyl ester (13924-94-2)

Guidance literature:

With ammonia; In tetrahydrofuran; at 0 - 25 ℃;

Reference yield: 78.0%

C14H15N3O3 (1204527-84-3) → 5-amino-pyrazine-2-carboxylic acid methyl ester (13924-94-2)

Guidance literature:

C₁₄H₁₅N₃O₃; With trifluoroacetic acid; at 60 ℃; for 1h;

With sodium hydrogencarbonate; at 20 ℃;

Reference yield: 49.0%

methanol (67-56-1) + 2-amino-5-cyanopyrazine (113305-94-5) → 5-amino-pyrazine-2-carboxylic acid methyl ester (13924-94-2)

Guidance literature:

methanol; 2-amino-5-cyanopyrazine; With boron trifluoride diethyl etherate; for 2h; Reflux;

With water; sodium hydrogencarbonate; In methanol; ethyl acetate;

upstream raw materials:

5-fluoro-pyrazine-2-carboxylic acid methyl ester

methanol

2-amino-5-cyanopyrazine

C₁₄H₁₅N₃O₃

Downstream raw materials:

methyl 5-amino-6-bromopyrazine-2-carboxylate

5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)propionylamino]-pyrazine-2-carboxylic acid methyl ester

5-[3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazine-2-carboxylic acid ethyl ester

3-(4-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide