AKOS BRN-1021

Base Information

• Chemical Name: AKOS BRN-1021
• CAS No.: 1007170-24-2
• Molecular Formula: C13H12BClO3
• Molecular Weight: 262.5
• Hs Code.: 2931900090
• Mol file: 1007170-24-2.mol

Synonyms:AKOS BRN-1021;3-Benzyloxy-4-chlorophenylboronic acid

Chemical Property of AKOS BRN-1021

Chemical Property:

• PSA: 49.69000
• LogP: 1.59880
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

3-Benzyloxy-4-chlorophenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BRN-1021

There total 1 articles about AKOS BRN-1021 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Triisopropyl borate (5419-55-6) + benzyl-(2-chloro-5-iodo-phenyl)-ether (859776-41-3) → [3-(benzyloxy)-4-chlorophenyl]boronic acid (1007170-24-2)

Guidance literature:

benzyl-(2-chloro-5-iodo-phenyl)-ether; With isopropylmagnesium chloride; In tetrahydrofuran; at -50 - -10 ℃; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; at -10 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 53.0%

[3-(benzyloxy)-4-chlorophenyl]boronic acid (1007170-24-2) + methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate (170235-19-5) → methyl 6-[3-(benzyloxy)-4-chlorophenyl]-5-hydroxypyridine-2-carboxylate (1007170-25-3)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 10h; Inert atmosphere;

Reference yield: 50.0%

methyl 5-amino-6-bromopyrazine-2-carboxylate (1076198-49-6) + [3-(benzyloxy)-4-chlorophenyl]boronic acid (1007170-24-2) → methyl 5-amino-6-[3-(benzyloxy)-4-chlorophenyl]pyrazine-2-carboxylate

Guidance literature:

With sodium carbonate; bis(benzonitrile)palladium(II) dichloride; n-butyl-diphenylphosphane; In ethanol; water; toluene; for 5.5h; Inert atmosphere; Reflux;

upstream raw materials:

Triisopropyl borate

benzyl-(2-chloro-5-iodo-phenyl)-ether

Downstream raw materials:

methyl 6-[3-(benzyloxy)-4-chlorophenyl]-5-hydroxypyridine-2-carboxylate

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