[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol

Base Information

Chemical Name:[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol
CAS No.:160709-02-4
Molecular Formula:C14 H15 F2 N3 O2
Molecular Weight:295.289
Hs Code.:
European Community (EC) Number:824-583-3
UNII:F6PWB58JT6
DSSTox Substance ID:DTXSID301107737
Mol file:160709-02-4.mol

Synonyms:160709-02-4;D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-;[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol;((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol;165877-21-4;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;(cis-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,;F6PWB58JT6;SCHEMBL4543842;DTXSID301107737;AC-28320;AS-75016;CS-0010881;C13236;A928091;[(3R,5R)-5-(2,4-difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-yl]methanol;((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluoro phenyl)tetrahydrofuran-3-yl)methanol;D-threo-Pentitol,2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-

Suppliers and Price of [(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,?5-?Anhydro-?1,?3,?4-?trideoxy-?2-?C-?(2,?4-?difluorophenyl)?-?4-?(hydroxymethyl)?-?1-?(1H-?1,?2,?4-?triazol-?1-?yl)?-D-?threo-?pentitol
500mg
$ 55.00

Medical Isotopes, Inc.
2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
25 g
$ 2475.00

Medical Isotopes, Inc.
2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
500 mg
$ 585.00

J&W Pharmlab
3R,5R-[5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-methanol 96%
50mg
$ 398.00

J&W Pharmlab
3R,5R-[5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-methanol 96%
250mg
$ 998.00

Crysdot
((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol 95+%
10g
$ 878.00

Crysdot
((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol 95+%
5g
$ 584.00

Alichem
((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol
5g
$ 333.30

Total 37 raw suppliers

Chemical Property of [(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol

Chemical Property:

Boiling Point:457.6±55.0 °C(Predicted)
PKA:14.81±0.10(Predicted)
PSA：60.17000
Density:1.42±0.1 g/cm3(Predicted)
LogP:1.48060
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:295.11323305
Heavy Atom Count:21
Complexity:363

Purity/Quality:

99%, ^*data from raw suppliers

2,?5-?Anhydro-?1,?3,?4-?trideoxy-?2-?C-?(2,?4-?difluorophenyl)?-?4-?(hydroxymethyl)?-?1-?(1H-?1,?2,?4-?triazol-?1-?yl)?-D-?threo-?pentitol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(COC1(CN2C=NC=N2)C3=C(C=C(C=C3)F)F)CO
Isomeric SMILES:C1[C@@H](CO[C@@]1(CN2C=NC=N2)C3=C(C=C(C=C3)F)F)CO
Uses 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol is building block to synthesize key intermediates towards synthesis of highly active azole antifungals Sch 51048, Sch 56592 and Sch 45012. It is also an impurity/intermediate for posaconazole (P689600).

Technology Process of [(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol

There total 32 articles about [(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 165115-83-3
1-[(2R,4R)-4-Benzyloxymethyl-2-(2,4-difluoro-phenyl)-tetrahydro-furan-2-ylmethyl]-1H-[1,2,4]triazole

: 160709-02-4
((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1016/0040-4039(96)01203-8

Reference yield: 94.0%

: 160668-66-6
1-[(2R,4S)-2-(2,4-Difluoro-phenyl)-4-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-ylmethyl]-1H-[1,2,4]triazole

: 160709-02-4
((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 24h;
DOI:10.1016/0040-4039(94)88071-9

Reference yield: 75.0%

: 41253-21-8
sodium triazole

: 182210-71-5
((3R,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-yl)methanol

: 160709-02-4
((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In N,N-dimethyl-formamide; at 100 ℃; for 24h;
DOI:10.1016/0040-4039(96)01203-8