2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE
• CAS No.: 14665-75-9
• Molecular Formula: C8H9NO2.ClH
• Molecular Weight: 187.626
• Mol file: 14665-75-9.mol

Synonyms:2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE;2-AMino-3'-hydroxy-acetophenone HCl

Chemical Property of 2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE

Chemical Property:

• Melting Point: 221–222°C
• PSA: 63.32000
• LogP: 2.03590
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

2-Amino-3’-hydroxy-acetophenoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Amino-3’-hydroxy-acetophenone Hydrochloride is a reactant in the synthesis of TRPM8 modulators.

Technology Process of 2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE

There total 2 articles about 2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(3-hydroxyphenyl)ethanone (2491-37-4) → 2-amino-1-(3-hydroxy-phenyl)-ethanone; hydrochloride (14665-75-9)

Guidance literature:

2-bromo-1-(3-hydroxyphenyl)ethanone; With hexamethylenetetramine; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In ethanol; water; at 45 ℃; for 1h;

DOI:10.1248/cpb.c15-00261

Reference yield:

2-azido-1-(3-hydroxyphenyl)ethan-1-one (344359-52-0) → 2-amino-1-(3-hydroxy-phenyl)-ethanone; hydrochloride (14665-75-9)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; at 0 - 20 ℃;

Reference yield:

fenofibric acid (42017-89-0) + 2-amino-1-(3-hydroxy-phenyl)-ethanone; hydrochloride (14665-75-9) → 2-(4-(4-chlorobenzoyl)phenoxy)-N-(2-(3-hydroxyphenyl)-2-oxoethyl)-2-methylpropanamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1248/cpb.c15-00261

upstream raw materials:

2-bromo-1-(3-hydroxyphenyl)ethanone

2-azido-1-(3-hydroxyphenyl)ethan-1-one

Downstream raw materials:

3,6-bis-(3-hydroxy-phenyl)-2,5-dihydro-pyrazine

Refernces

• 1、 -. "COMPOUNDS USEFUL AS MODULATORS OF TRPM8". Paragraph 0843. . Retrieved 2016/03/29.