Desacetyl-7-ACA lactone

Base Information

Chemical Name:Desacetyl-7-ACA lactone
CAS No.:184696-69-3
Molecular Formula:C8H8N2O3S
Molecular Weight:212.229
Hs Code.:
UNII:6CB77DWP49

Synonyms:184696-69-3;Desacetyl-7-ACA lactone;Cefazedone Impurity 12;6CB77DWP49;(5aR,6R)-6-Amino-5a,6-dihydro-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione;(5aR,6R)-6-amino-5a,6-dihydroazeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(3H,4H)-dione;3H,7H-Azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione, 6-amino-5a,6-dihydro-, (5aR,6R)-;3H,7H-Azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione, 6-amino-5a,6-dihydro-, (5aR-trans)-;6-Amino-5a,6-dihydro-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione, (5aR,6R)-

Suppliers and Price of Desacetyl-7-ACA lactone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 11 raw suppliers

Chemical Property of Desacetyl-7-ACA lactone

Chemical Property:

Boiling Point:628.8±55.0 °C(Predicted)
PKA:4.51±0.20(Predicted)
PSA：97.93000
Density:1.71±0.1 g/cm3(Predicted)
LogP:-0.32210
XLogP3:-1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:212.02556330
Heavy Atom Count:14
Complexity:379

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(C(=O)O1)N3C(C(C3=O)N)SC2
Isomeric SMILES:C1C2=C(C(=O)O1)N3[C@@H]([C@@H](C3=O)N)SC2
Uses Desacetyl-7-ACA Lactone is a lactone derivative of 7-Aminocephalosporanic acid (A603415), a fundamental building block in the synthesis of cephalosporin antibiotics.

Technology Process of Desacetyl-7-ACA lactone

There total 2 articles about Desacetyl-7-ACA lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 184696-69-3
6t-amino-(5ar)-5a,6-dihydro-3H,4H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7-dione

: 24701-69-7
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: With methanesulfonic acid; trifluorormethanesulfonic acid; In methanol; at 13 - 14 ℃; for 0.75h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1002/jlac.199619961106

Reference yield:

: 67-56-1
methanol

: 957-68-6
7-Aminocephalosporanic acid

: 184696-69-3
6t-amino-(5ar)-5a,6-dihydro-3H,4H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7-dione

: 24701-69-7
(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: With methanesulfonic acid; trifluorormethanesulfonic acid; at 13 - 14 ℃; for 0.75h; Yield given. Yields of byproduct given;
DOI:10.1002/jlac.199619961106