(1R,2R)-Indan-1,2-diol, 97%

Base Information

• Chemical Name: (1R,2R)-Indan-1,2-diol, 97%
• CAS No.: 67528-23-8
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Mol file: 67528-23-8.mol

Synonyms:(1R,2R)-Indan-1,2-diol, 97%

Chemical Property of (1R,2R)-Indan-1,2-diol, 97%

Chemical Property:

• Melting Point: 184-186 °C
• Boiling Point: 288.5±40.0 °C(Predicted)
• PKA: 13.70±0.40(Predicted)
• PSA: 50.19000
• Density: 1.334±0.06 g/cm3(Predicted)
• LogP: 1.05800

Purity/Quality:

98% ^*data from raw suppliers

(1R,2R)-INDAN-1,2-DIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2R)-Indan-1,2-diol, 97%

There total 149 articles about (1R,2R)-Indan-1,2-diol, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-2-bromo-1-indanol (10368-44-2,78684-69-2) + acetic anhydride (108-24-7) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

trans-2-bromo-1-indanol; acetic anhydride; at 65 ℃; for 5h;

With sodium hydroxide; In water;

DOI:10.1016/S0957-4166(01)00006-4

Reference yield: 88.0%

cis-1,2-dihydroxyindane carbonate (19597-98-9,67131-50-4) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1002/anie.201406645

Reference yield: 87.0%

1-indene (95-13-6) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

1-indene; With sodium periodate; acetic acid; lithium bromide; at 95 ℃; for 18h;

With potassium carbonate; In methanol; at 25 ℃; for 24h;

DOI:10.1021/ol052080n

upstream raw materials:

1-indene

cis-indane-1,2-diol

indan-2-ol

(1R,2S)-1,2-diacetoxyindane

Downstream raw materials:

2-indanone

2-(2-oxoethyl)benzaldehyde

cis-indane-1,2-diol

2-butyl-(3ar,8ac)-8,8a-dihydro-3aH-indeno[1,2-d][1,3,2]dioxaborole

Refernces

• 1、 Buljubasic, Isa,Hall, Mélanie,Laggner, Olivia,Merusic, Kemal,Reiter, Tamara,Tassano, Erika,Vogel, Andreas. "Regioselective biocatalytic self-sufficient Tishchenko-type reactionviaformal intramolecular hydride transfer". supporting information. p. 6340 - 6343. Retrieved 2020/06/21.
• 2、 Pilevar, Afsaneh,Hosseini, Abolfazl,Becker, Jonathan,Schreiner, Peter R.. "Syn-dihydroxylation of alkenes using a sterically demanding cyclic diacyl peroxide". . p. 12377 - 12386. Retrieved 2019/10/11.