N-[3-(2-amino-5-thiazolyl)phenyl]-4-(trifluoromethyl)-2-Pyrimidinamine

Base Information

Chemical Name:N-[3-(2-amino-5-thiazolyl)phenyl]-4-(trifluoromethyl)-2-Pyrimidinamine
CAS No.:1312572-13-6
Molecular Formula:C₁₄H₁₀F₃N₅S
Molecular Weight:337.328
Hs Code.:

Synonyms:N-[3-(2-amino-5-thiazolyl)phenyl]-4-(trifluoromethyl)-2-Pyrimidinamine

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Chemical Property of N-[3-(2-amino-5-thiazolyl)phenyl]-4-(trifluoromethyl)-2-Pyrimidinamine

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Technology Process of N-[3-(2-amino-5-thiazolyl)phenyl]-4-(trifluoromethyl)-2-Pyrimidinamine

There total 5 articles about N-[3-(2-amino-5-thiazolyl)phenyl]-4-(trifluoromethyl)-2-Pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.7%

: 1312572-74-9
tert-butyl [5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbamate

: 1312572-13-6
N-[3-(2-amino-1,3-thiazol-5-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: tert-butyl [5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h; Inert atmosphere;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1312572-13-6
N-[3-(2-amino-1,3-thiazol-5-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 1,4-dioxane / 100 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 100 °C

3: potassium fluoride; catacxium A / palladium diacetate / water; tetrahydrofuran / 17 h / 75 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 17 h / 20 °C / Inert atmosphere

With potassium fluoride; methanesulfonic acid; potassium acetate; trifluoroacetic acid; catacxium A; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1312572-13-6
N-[3-(2-amino-1,3-thiazol-5-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 1,4-dioxane / 100 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 100 °C

3: potassium fluoride; catacxium A / palladium diacetate / water; tetrahydrofuran / 17 h / 75 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 17 h / 20 °C / Inert atmosphere

With potassium fluoride; methanesulfonic acid; potassium acetate; trifluoroacetic acid; catacxium A; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;