Technology Process of 2-aMino-5-[[4-[(1-Methylcyclohexyl)Methoxy]phenyl]Methyl]-4(5H)-thiazolone
There total 5 articles about 2-aMino-5-[[4-[(1-Methylcyclohexyl)Methoxy]phenyl]Methyl]-4(5H)-thiazolone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium acetate;
In
2-methoxy-ethanol;
at 100 ℃;
for 10h;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86.9 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
3: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C
4: 80.4 percent / NaOAc / 2-methoxy-ethanol / 10 h / 100 °C
With
copper(I) oxide; hydrogenchloride; hydrogen; sodium acetate; sodium hydride; sodium nitrite;
palladium on activated charcoal;
In
methanol; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86.9 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
3: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C
4: 80.4 percent / NaOAc / 2-methoxy-ethanol / 10 h / 100 °C
With
copper(I) oxide; hydrogenchloride; hydrogen; sodium acetate; sodium hydride; sodium nitrite;
palladium on activated charcoal;
In
methanol; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1248/cpb.30.3580