14064-13-2

Usage

Uses

Used in Organic Synthesis:
1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE is used as a synthetic building block for the creation of various organic compounds. Its unique structure allows it to be a versatile intermediate in the synthesis of a wide range of chemical products, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Pharmaceutical Industry:
1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE is used as a key intermediate in the development of new pharmaceutical compounds. Its chemical properties make it suitable for the synthesis of various drug molecules, contributing to the advancement of novel treatments for various medical conditions.
Used in Agrochemical Industry:
1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE is used as a starting material in the synthesis of agrochemicals, such as pesticides and herbicides. Its application in this industry helps in the development of more effective and environmentally friendly products for agricultural use.
Used in Specialty Chemicals Industry:
1-HYDROXYMETHYL-1-METHYLCYCLOHEXANE is used as a raw material in the production of specialty chemicals, which are high-value chemicals used in various applications, such as coatings, adhesives, and sealants. Its unique properties make it an essential component in the formulation of these high-performance materials.

InChI:InChI=1/C8H16O/c1-8(7-9)5-3-2-4-6-8/h9H,2-7H2,1H3

Upstream product

• 931-96-4 1-methyl-3-cyclohexene-1-carboxaldehyde 
• 825-04-7 methyl 1-methylcyclohexanecarboxylate 
• 67-56-1 methanol 
• 82166-21-0 methyl cyclohexane 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 502-41-0 cycloheptanol 
• 7731-29-5 trans-4-methylcyclohexan-1-ol 
• 7443-52-9 (+/-)-trans-2-methylcyclohexanol 
• 5454-79-5 cis-3-methylcyclohexanol 
• 6493-80-7 methyl 1-methyl-3-cyclohexenecarboxylate 
• 590-67-0 1-Methylcyclohexanol 
• 18448-47-0 methyl cyclohex-1-ene-1-carboxylate 
• 4845-04-9 1-cyclohexene-1-methanol 
• 16646-42-7 1-methyl-3-cyclohexenecarboxylic acid 

Downstream Products

• 102944-34-3 adipic acid bis-(1-methyl-cyclohexylmethyl ester) 
• 10578-32-2 decanedioic acid bis-(1-methyl-cyclohexylmethyl ester) 
• 34541-92-9 Bis-(1-methylcyclohexylmethyl)aether 
• 85003-01-6 2-(1-Methyl-cyclohexylmethoxy)-5-nitro-pyridine 
• 825-04-7 methyl 1-methylcyclohexanecarboxylate 
• 125518-59-4 5-<<4-<(1-methylcyclohexyl)methoxy>phenyl>sulfonyl>-2,4-thiazolidinedione 
• 85002-76-2 4-(1-methylcyclohexylmethoxy)nitrobenzene 
• 6140-64-3 1-methylcyclohexanecarbaldehyde 
• 219653-61-9 (S)-2-(2-Benzoyl-phenylamino)-3-[4-(1-methyl-cyclohexylmethoxy)-phenyl]-propionic acid methyl ester 
• 1678-91-7 ethyl-cyclohexane 
• 638-04-0 1,3-dimethylcyclohexane 
• 4126-78-7 methylcycloheptane 
• 1124-98-7 1-ethylcyclohexane-1-carboxylic acid 
• 14064-12-1 (1-methylcyclohexyl)methyl-4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Preparation of isoquinazolines: Via metal-free [4 + 2] cycloaddition of ynamides with nitriles

TfOH-mediated [4 + 2] cycloaddition of ynamides with nitriles to construct 1,2-dihydroquinazolines is realized by a direct reaction in moderate to excellent yields (up to 93%) in a stereospecific manner. A rapid and efficient strategy has been employed for the syntheses of alkyl-substituted 1,2-dihydroquinazoline derivatives, and it exhibits good functional group tolerance, has a short reaction time, shows excellent diastereoselectivity, and is a simple and high-yielding reaction.

Hemilabile Benzyl Ether Enables Γ-C(sp3)-H Carbonylation and Olefination of Alcohols

Pd-catalyzed C(sp3)-H activation of alcohol typically shows β-selectivity due to the required distance between the chelating atom in the attached directing group and the targeted C-H bonds. Herein we report the design of a hemilabile directing group which exploits the chelation of a readily removable benzyl ether moiety to direct Γ- or δ-C-H carbonylation and olefination of alcohols. The utility of this approach is also demonstrated in the late-stage C-H functionalization of β-estradiol to rapidly prepare desired analogues that required multi-step syntheses with classical methods.

Hemilabile Benzyl Ether Enables γ-C(sp3)-H Carbonylation and Olefination of Alcohols

Pd-catalyzed C(sp3)-H activation of alcohol typically shows β-selectivity due to the required distance between the chelating atom in the attached directing group and the targeted C-H bonds. Herein we report the design of a hemilabile directing group which exploits the chelation of a readily removable benzyl ether moiety to direct γ- or δ-C-H carbonylation and olefination of alcohols. The utility of this approach is also demonstrated in the late-stage C-H functionalization of β-estradiol to rapidly prepare desired analogues that required multi-step syntheses with classical methods.

Catalytic Reduction of Alkyl and Aryl Bromides Using Propan-2-ol

Milstein's complex, (PNN)RuHCl(CO), catalyzes the efficient reduction of aryl and alkyl halides under relatively mild conditions by using propan-2-ol and a base. Sterically hindered tertiary and neopentyl substrates are reduced efficiently, as well as more functionalized aryl and alkyl bromides. The reduction process is proposed to occur by radical abstraction/hydrodehalogenation steps at ruthenium. Our research represents a safer and more sustainable alternative to typical silane, lithium aluminium hydride, and tin-based conditions for these reductions.

CYCLOALKYL METHOXYBENZYL PHENYL PYRAN DERIVATIVES AS SODIUM DEPENDENT GLUCOSE CO TRANSPORTER (SGLT2) INHIBITORS

The invention relates to the cycloalkyl methoxybenzyl phenyl pyran derivatives as Sodium dependent glucose co transporter (SGLT) inhibitors, particularly SGLT2 and method of treating diseases, conditions and/or disorders inhibited by SGLT2 with them, and processes for preparing them.

ANDROGEN RECEPTOT-ABLATIVE AGENTS

Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating

Pharmacological exploitation of the peroxisome proliferator-activated receptor γ agonist ciglitazone to develop a novel class of androgen receptor-ablative agents

On the basis of our finding that the peroxisome proliferator-activated receptor γ (PPARγ) agonist ciglitazone at high doses was able to mediate PPARγ-independent transcriptional repression of androgen receptor (AR) in a tumor cell-specific manner, we used

Practical and efficient method for amino acid derivatives containing β-quaternary center: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors

A practical and efficient route toward synthesis of amino acid derivatives containing β-quaternary center has been developed using diastereoselective Strecker reaction. The method was employed for preparation of >100 g of β-methylcyclohexyl glycine deriva

NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

CYCLOBUTENEDIONE GROUPS-CONTAINING COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.