ledipasvir interMediate

Base Information

Chemical Name:ledipasvir interMediate
CAS No.:1441673-92-2
Molecular Formula:C12H19NO4
Molecular Weight:279.378
Hs Code.:
Mol file:1441673-92-2.mol

Synonyms:potassiuM (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt (1:1);(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt;edipasvir interMediate;Ledipasvir INT 1;5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt (1:1), (6S)-;5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt, (6S)-

Suppliers and Price of ledipasvir interMediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(6s)-5-Azaspiro[2.4]Heptane-5,6-DicarboxylicAcid5-(1,1-Dimethylethyl)EsterPotassiumSalt(1:1)
5mg
$ 60.00

Crysdot
Potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95+%
1g
$ 226.00

ChemScene
Potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate
1g
$ 68.00

Chemenu
potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95%
5g
$ 645.00

Chemenu
potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95%
1g
$ 271.00

Alichem
Potassium(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate
5g
$ 690.00

AK Scientific
(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylicacid5-(1,1-dimethylethyl)esterpotassiumsalt
100mg
$ 84.00

Total 63 raw suppliers

Chemical Property of ledipasvir interMediate

Chemical Property:

PSA：69.67000
LogP:0.46380
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

(6s)-5-Azaspiro[2.4]Heptane-5,6-DicarboxylicAcid5-(1,1-Dimethylethyl)EsterPotassiumSalt(1:1) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ledipasvir interMediate

There total 8 articles about ledipasvir interMediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1129634-44-1,1454843-77-6,1454843-78-7
(6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid

: 1441673-92-2
(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate

Guidance literature:: With potassium tert-butylate; In 2-methyltetrahydrofuran; at 20 - 40 ℃; for 3.5h;

Reference yield:

: 39590-81-3
[1-(hydroxymethyl)cyclopropyl]methanol

: 1441673-92-2
(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 3 h / 10 °C

2: sodium hydride / N,N-dimethyl acetamide; mineral oil / 4.5 h / 0 - 11 °C

3: lithium hydroxide; water / 2-methyltetrahydrofuran / 50 °C / Inert atmosphere

4: (1S,2R)-1-amino-2-indanol / 2-methyltetrahydrofuran / 1.17 h / 55 °C

5: potassium tert-butylate / 2-methyltetrahydrofuran / 3.5 h / 20 - 40 °C

With 1H-imidazole; potassium tert-butylate; water; iodine; sodium hydride; (1S,2R)-1-amino-2-indanol; triphenylphosphine; lithium hydroxide; In 2-methyltetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; mineral oil;

Reference yield:

: 83321-23-7
1,1-bis(iodomethyl)cyclopropane

: 1441673-92-2
(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 4.5 h / 0 - 11 °C

2: lithium hydroxide; water / 2-methyltetrahydrofuran / 50 °C / Inert atmosphere

3: (1S,2R)-1-amino-2-indanol / 2-methyltetrahydrofuran / 1.17 h / 55 °C

4: potassium tert-butylate / 2-methyltetrahydrofuran / 3.5 h / 20 - 40 °C

With potassium tert-butylate; water; sodium hydride; (1S,2R)-1-amino-2-indanol; lithium hydroxide; In 2-methyltetrahydrofuran; N,N-dimethyl acetamide; mineral oil;