(R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine

Base Information

• Chemical Name: (R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine
• CAS No.: 1314419-66-3
• Molecular Formula: C₁₅H₂₀FNO₃
• Molecular Weight: 281.327
• Hs Code.: 2933998090
• Mol file: 1314419-66-3.mol

Synonyms:(R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine;(R)-tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate

Chemical Property of (R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine

Chemical Property:

• PSA: 38.77000
• LogP: 3.15180

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine

There total 4 articles about (R)-N-Boc-3-(4-fluorophenoxy)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-Fluorophenol (371-41-5) + 3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester (141699-57-2) → tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate (950648-92-7,1314419-66-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; for 120h;

Reference yield:

4-Fluorophenol (371-41-5) + (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) → (S)-tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate (1314419-66-3)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine (103057-44-9,83220-73-9) → tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate (950648-92-7,1314419-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 18.17 h / 0 °C

2: potassium carbonate / acetonitrile / 120 h / 85 °C

With pyridine; dmap; potassium carbonate; In dichloromethane; acetonitrile;

upstream raw materials:

4-Fluorophenol

3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester

N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

Downstream raw materials:

(S)-3-(4-fluorophenoxy)pyrrolidine

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