(S)-2-(1-HYDROXY-1-METHYLETHYL) PYRROLIDINE,

Base Information

• Chemical Name: (S)-2-(1-HYDROXY-1-METHYLETHYL) PYRROLIDINE,
• CAS No.: 92053-25-3
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Mol file: 92053-25-3.mol

Synonyms:(S)-2-(1-HYDROXY-1-METHYLETHYL) PYRROLIDINE,;(2S)-a,a-diMethyl-2-PyrrolidineMethanol;(2S)-N-α,α-diMethyl-2-PyrrolidineMethanol;(S)-2-(pyrrolidin-2-yl)propan-2-ol;(2S)--A,A-DIMETHYL-2-PYRROLIDINEMETHANOL HCL;2-[(2S)-pyrrolidin-2-yl]propan-2-ol

Chemical Property of (S)-2-(1-HYDROXY-1-METHYLETHYL) PYRROLIDINE,

Chemical Property:

• Boiling Point: 195.7±13.0 °C(Predicted)
• PKA: 14.91±0.29(Predicted)
• PSA: 32.26000
• Density: 0.978±0.06 g/cm3(Predicted)
• LogP: 0.83810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(Pyrrolidin-2-yl)propan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-(1-HYDROXY-1-METHYLETHYL) PYRROLIDINE,

There total 14 articles about (S)-2-(1-HYDROXY-1-METHYLETHYL) PYRROLIDINE, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine (92053-25-3,214626-52-5)

Guidance literature:

Reference yield: 96.0%

(S)-(-)-1-benzyl-2-(1-hydroxy-1-methylethyl)-pyrrolidine (118970-92-6) → (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine (92053-25-3,214626-52-5)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; for 72h; under 760.051 Torr;

DOI:10.1039/b001730m

Reference yield: 92.0%

(S)-tert-butyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate → (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine (92053-25-3,214626-52-5)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1016/j.tet.2019.130492

upstream raw materials:

(2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine

(S)-(-)-1-benzyl-2-(1-hydroxy-1-methylethyl)-pyrrolidine

methyl (2S)-pyrrolidine carboxylate

N-benzyl-(S)-proline methyl ester

Downstream raw materials:

(S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine

(S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine

C₂₁H₂₃NO₃

C₁₄H₂₀BNO