(S)-Benzyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (S)-Benzyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate
• CAS No.: 51207-68-2
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.337
• DSSTox Substance ID: DTXSID801154733
• Nikkaji Number: J1.396.365G
• Mol file: 51207-68-2.mol

Synonyms:51207-68-2;(S)-Benzyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate;benzyl (2S)-2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate;SCHEMBL6304388;BVTSTCCUNHXPRO-ZDUSSCGKSA-N;DTXSID801154733;CS-0104801;(2S)-N-Cbz-,-dimethyl-2-pyrrolidinemethanol;(2S)-N-Cbz-|A,|A-dimethyl-2-pyrrolidinemethanol;EN300-22177560;(S)-Benzyl2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate;Phenylmethyl (2S)-2-(1-hydroxy-1-methylethyl)-1-pyrrolidinecarboxylate;(s)-2-(1-hydroxy-1-methyl-ethyl)-pyrrolidine-1-carboxylic acid benzyl ester

Chemical Property of (S)-Benzyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 2.49640
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 263.15214353
• Heavy Atom Count: 19
• Complexity: 311

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C1CCCN1C(=O)OCC2=CC=CC=C2)O
• Isomeric SMILES: CC(C)([C@@H]1CCCN1C(=O)OCC2=CC=CC=C2)O

Technology Process of (S)-Benzyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate

There total 9 articles about (S)-Benzyl 2-(2-hydroxypropan-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-carbobenzyloxy-L-proline methyl ester (5211-23-4) + methyl iodide (74-88-4) → (2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine (51207-68-2)

Guidance literature:

methyl iodide; With magnesium; In diethyl ether;

N-carbobenzyloxy-L-proline methyl ester; In diethyl ether; for 3h; Further stages.; Heating;

DOI:10.1039/b004450o

Reference yield: 72.0%

N-carbobenzyloxy-L-proline methyl ester (5211-23-4) → (2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine (51207-68-2)

Guidance literature:

With methylmagnesium bromide; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

(S)-2-(1-hydroxy-1-methylethyl)pyrrolidine hydrochloride (474317-28-7) + benzyl chloroformate (501-53-1,94274-21-2) → (2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine (51207-68-2)

Guidance literature:

With triethylamine; In water;

upstream raw materials:

methyl magnesium iodide

N-carbobenzyloxy-L-proline methyl ester

methyl iodide

methyl (2S)-pyrrolidine carboxylate

Downstream raw materials:

(S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine

(S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine

(8S,8aS)-8-hydroxy-8-methyl-6(Z)-<6-oxo-2(R),5-dimethyl-7(R)-(tert-butyldiphenylsiloxy)-4(E)-octenylidene>octahydroindolizidine

(1S ,7aS)-tetrahydro-1-methyl-1-<6-(benzyloxy)-4(R)-methyl-2-(trimethylsilyl)-2(Z)-hexenyl>-1H,3H-pyrrolo<1,2-c>oxazol-3-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 51207-68-2 (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send