2-AMINO-4,5-DIMETHYLBENZONITRILE

Base Information

• Chemical Name: 2-AMINO-4,5-DIMETHYLBENZONITRILE
• CAS No.: 28568-03-8
• Molecular Formula: C9H10N2
• Molecular Weight: 146.192
• Mol file: 28568-03-8.mol

Synonyms:2-AMINO-4,5-DIMETHYLBENZONITRILE

Chemical Property of 2-AMINO-4,5-DIMETHYLBENZONITRILE

Chemical Property:

• PSA: 49.81000
• LogP: 2.33848

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4,5-dimethylbenzonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMINO-4,5-DIMETHYLBENZONITRILE

There total 4 articles about 2-AMINO-4,5-DIMETHYLBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

copper(l) cyanide + 2-iodo-4,5-dimethylaniline (117832-17-4) → 4,5-dimethyl-2-aminobenzonitrile (28568-03-8)

Guidance literature:

copper(l) cyanide; 2-iodo-4,5-dimethylaniline; In N,N-dimethyl-formamide; at 150 - 160 ℃; for 1.5h;

With ammonium hydroxide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

4-amino-o-xylene (95-64-7) → 4,5-dimethyl-2-aminobenzonitrile (28568-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; iodine / water; methanol / 1 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 1.5 h / 150 - 160 °C

2.2: 20 °C

With iodine; sodium hydrogencarbonate; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

2,3-dimethyl-6-nitrobenzonitrile (15089-77-7) + 4,5-dimethyl-2-nitrobenzenamine (6972-71-0) + iron (7439-89-6) → 4,5-dimethyl-2-aminobenzonitrile (28568-03-8)

Guidance literature:

With sodium carbonate; sodium nitrite; In hydrogenchloride; water; acetic acid; toluene;

upstream raw materials:

2,3-dimethyl-6-nitrobenzonitrile

4,5-dimethyl-2-nitrobenzenamine

iron

4-amino-o-xylene

Downstream raw materials:

2-amino-4,5-dimethylbenzoic acid

Refernces

• 1、 -. "QUINAZOLINEDIONE DERIVATIVE". . . Retrieved 2015/03/16.