Pyrano[2,3-c]pyrazol-4(1H)-one, 1,3-diMethyl-6-phenyl-

Base Information

• Chemical Name: Pyrano[2,3-c]pyrazol-4(1H)-one, 1,3-diMethyl-6-phenyl-
• CAS No.: 137527-47-0
• Molecular Formula: C14H12N2O2
• Molecular Weight: 240.25728
• Mol file: 137527-47-0.mol

Synonyms:Pyrano[2,3-c]pyrazol-4(1H)-one, 1,3-diMethyl-6-phenyl-

Chemical Property of Pyrano[2,3-c]pyrazol-4(1H)-one, 1,3-diMethyl-6-phenyl-

Chemical Property:

• PSA: 48.03000
• LogP: 2.50190

Purity/Quality:

1,3-Dimethyl-6-phenylpyrano[2,3-c]pyrazol-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrano[2,3-c]pyrazol-4(1H)-one, 1,3-diMethyl-6-phenyl-

There total 7 articles about Pyrano[2,3-c]pyrazol-4(1H)-one, 1,3-diMethyl-6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

5-bromo-5,6-dihydro-1,3-dimethyl-6-phenylpyrano<2,3-c>pyrazol-4(1H)-one (137527-46-9) → 1,3-dimethyl-6-phenylpyrano<2,3-c>pyrazol-4(1H)-one (137527-47-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 90 ℃; for 1h;

Reference yield:

phenylpropyolic acid (637-44-5) → 1,3-dimethyl-6-phenylpyrano<2,3-c>pyrazol-4(1H)-one (137527-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 80 percent / SOCl₂ / CH₂Cl₂ / 16 h / 40 °C

2.1: (Ca(OH)2 / dioxane / 6 h / Heating

2.2: K₂CO₃ / acetone / 3.5 h / Heating

With calcium hydroxide; thionyl chloride; In 1,4-dioxane; dichloromethane;

DOI:10.1055/s-2005-872078

Reference yield:

phenylpropiolyl chloride (7299-58-3) + 1,3-dimethyl-5-pyrazolone (2749-59-9) → 1,3-dimethyl-6-phenylpyrano<2,3-c>pyrazol-4(1H)-one (137527-47-0)

Guidance literature:

phenylpropiolyl chloride; 1,3-dimethyl-5-pyrazolone; With calcium hydroxide; In 1,4-dioxane; for 6h; Heating;

With potassium carbonate; In acetone; for 3.5h; Heating;

DOI:10.1055/s-2005-872078

upstream raw materials:

5-bromo-5,6-dihydro-1,3-dimethyl-6-phenylpyrano<2,3-c>pyrazol-4(1H)-one

phenylpropiolyl chloride

1,3-dimethyl-5-pyrazolone

phenylpropyolic acid