4-Ethoxycarbonyl-2-methyl-2-oxazoline

Base Information

• Chemical Name: 4-Ethoxycarbonyl-2-methyl-2-oxazoline
• CAS No.: 68683-04-5
• Molecular Weight: 0
• European Community (EC) Number: 614-704-6
• Mol file: 68683-04-5.mol

Synonyms:68683-04-5;ethyl 2-methyl-4,5-dihydrooxazole-4-carboxylate;(2S)-Ethyl-4-methyl-3,5-oxazolinecarboxylate;4-Ethoxycarbonyl-2-methyl-2-oxazoline;61999-29-9;Ethyl 2-methyl-4,5-dihydro-1,3-oxazole-4-carboxylate;SCHEMBL6602372;AB14234;FT-0690356;FT-0716118;A836352;2-methyl-4,5-dihydrooxazole-4-carboxylic acid ethyl ester;Ethyl 2-methyl-4,5-dihydro-1,3-oxazole-4-carboxylate #

Chemical Property of 4-Ethoxycarbonyl-2-methyl-2-oxazoline

Chemical Property:

• Vapor Pressure: 0.305mmHg at 25°C
• Boiling Point: 201.6°C at 760 mmHg
• Flash Point: 80.1°C
• Density: 1.21g/cm³
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 157.07389321
• Heavy Atom Count: 11
• Complexity: 188

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1COC(=N1)C

Technology Process of 4-Ethoxycarbonyl-2-methyl-2-oxazoline

There total 1 articles about 4-Ethoxycarbonyl-2-methyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ethyl acetimidate hydrochloride (2208-07-3) + L-serine ethyl ester hydrochloride (26348-61-8,104055-46-1) → ethyl (2-methyl-2-oxazolin-4-yl)carboxylate (68683-04-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 20.25h;

DOI:10.1021/jm0407613

Reference yield: 44.0%

ethyl (2-methyl-2-oxazolin-4-yl)carboxylate (68683-04-5) → 2-methyl-4-carbethoxy-1,3-oxazole (10200-43-8)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at -4 ℃; for 11h; Irradiation;

DOI:10.1021/jm0407613

Reference yield:

ethyl 2-methyloxaxoline-4-carboxylate + copper diacetate (142-71-2) + ethyl (2-methyl-2-oxazolin-4-yl)carboxylate (68683-04-5) + copper(I) bromide (7787-70-4) → 2-methyl-4-carbethoxy-1,3-oxazole (10200-43-8)

Guidance literature:

In benzene;

upstream raw materials:

ethyl acetimidate hydrochloride

L-serine ethyl ester hydrochloride

Downstream raw materials:

2-methyl-4-carbethoxy-1,3-oxazole

2-methyl-1,3-oxazol-4-carboxylic acid

2-methyl-1,3-oxazole-4-carbaldehyde

4-hydroxymethyl-2-methyloxazole