Potassium 1-trifluoroboratomethylthiomorpholine

Base Information

• Chemical Name: Potassium 1-trifluoroboratomethylthiomorpholine
• CAS No.: 1150654-80-0
• Molecular Formula: C5H10BF3NS.K
• Molecular Weight: 223.112
• Mol file: 1150654-80-0.mol

Synonyms:Potassium4-trifluoroboratomethylthiomorpholine

Chemical Property of Potassium 1-trifluoroboratomethylthiomorpholine

Chemical Property:

• PSA: 28.54000
• LogP: 1.77800

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Potassium 1-trifluoroboratomethylthiomorpholine

There total 1 articles about Potassium 1-trifluoroboratomethylthiomorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

Thiomorpholin (123-90-0) + potassium bromomethyl trifluoroborate → potassium (thiomorpholin-4-yl-methyl)trifluoroborate (1150654-80-0)

Guidance literature:

In tetrahydrofuran; at 80 ℃; for 16h;

DOI:10.1021/acs.joc.0c02958

Reference yield: 84.0%

Ethyl 4-hydroxybenzoate (120-47-8) + potassium (thiomorpholin-4-yl-methyl)trifluoroborate (1150654-80-0) → ethyl 4-hydroxy-3-(N-thiomorpholino)methylbenzoate

Guidance literature:

With copper diacetate; sodium acetate; In toluene; at 80 ℃; for 24h;

DOI:10.1021/jacs.7b06785

Reference yield: 36.0%

nicotinyl chloride (3099-31-8) + potassium (thiomorpholin-4-yl-methyl)trifluoroborate (1150654-80-0) → 4-(2-(pyridin-3-yl)ethyl)thiomorpholine

Guidance literature:

With C₃₈H₅₂Cl₃N₃Pd; potassium carbonate; In tert-Amyl alcohol; water; at 80 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.0c02958

upstream raw materials:

Thiomorpholin

Refernces

• 1、 Dai, Jin-Ling,Shao, Nan-Qi,Zhang, Jin,Jia, Run-Ping,Wang, Dong-Hui. "Cu(II)-Catalyzed ortho-Selective Aminomethylation of Phenols". supporting information. p. 12390 - 12393. Retrieved 2017/09/23.