4-Chloro-5,8-difluoroquinoline

Base Information

Chemical Name:4-Chloro-5,8-difluoroquinoline
CAS No.:874781-04-1
Molecular Formula:C₉H₄ClF₂N
Molecular Weight:199.587
Hs Code.:2933499090
European Community (EC) Number:804-529-5
DSSTox Substance ID:DTXSID10656133
Wikidata:Q82570641
Mol file:874781-04-1.mol

Synonyms:4-chloro-5,8-difluoroquinoline;874781-04-1;1208626-68-9;SCHEMBL19989867;DTXSID10656133;TQR0417;ZJB78104;MFCD03407958;AKOS005260552;SB67425;4-Chloro-5,8-difluoroquinoline, AldrichCPR;CS-0216832;FT-0735887;EN300-62119;Z431511714

Suppliers and Price of 4-Chloro-5,8-difluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-5,8-difluoroquinoline
500mg
$ 350.00

Sigma-Aldrich
4-Chloro-5,8-difluoroquinoline Aldrich
1g
$ 223.00

American Custom Chemicals Corporation
4-CHLORO-5,8-DIFLUOROQUINOLINE 95.00%
5G
$ 1759.28

American Custom Chemicals Corporation
4-CHLORO-5,8-DIFLUOROQUINOLINE 95.00%
2.5G
$ 1363.65

American Custom Chemicals Corporation
4-CHLORO-5,8-DIFLUOROQUINOLINE 95.00%
1G
$ 925.31

AK Scientific
4-Chloro-5,8-difluoroquinoline
1g
$ 340.00

Total 2 raw suppliers

Chemical Property of 4-Chloro-5,8-difluoroquinoline

Chemical Property:

Vapor Pressure:0.0171mmHg at 25°C
Boiling Point:263.2°C at 760 mmHg
Flash Point:113°C
PSA：12.89000
Density:1.455g/cm³
LogP:3.16640
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:199.0000331
Heavy Atom Count:13
Complexity:191

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5,8-difluoroquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C2C(=C1F)C(=CC=N2)Cl)F

Technology Process of 4-Chloro-5,8-difluoroquinoline

There total 3 articles about 4-Chloro-5,8-difluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 874804-43-0
5,7-difluoroquinolin-4-ol

: 874781-04-1,874831-46-6
4-chloro-5,7-difluoroquinoline

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Inert atmosphere;

Reference yield:

: 1071541-70-2
5-[(3,5-difluoro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 874781-04-1,874831-46-6
4-chloro-5,7-difluoroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / 1 h / 230 °C

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; In diphenylether; dichloromethane;

Reference yield:

: 372-39-4
3,5-difluoroaniline

: 874781-04-1,874831-46-6
4-chloro-5,7-difluoroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1 h / 105 °C / Inert atmosphere

1.2: 1 h / 105 °C / Inert atmosphere

2.1: diphenylether / 1 h / 230 °C

3.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; In diphenylether; dichloromethane;