BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-

Base Information

Chemical Name:BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-
CAS No.:863329-62-8
Molecular Formula:C31H27N3O8
Molecular Weight:569.571
Hs Code.:
Mol file:863329-62-8.mol

Synonyms:BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-;Sofosbuvir Impurity 2

Suppliers and Price of BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Benzamide,N-[1-(3,5-di-O-benzoyl-2-C-methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-
100mg
$ 450.00

Total 7 raw suppliers

Chemical Property of BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-

Chemical Property:

PKA:8.60±0.20(Predicted)
PSA：146.05000
Density:1.36±0.1 g/cm3(Predicted)
LogP:3.29960

Purity/Quality:

> 95% ^*data from raw suppliers

Benzamide,N-[1-(3,5-di-O-benzoyl-2-C-methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]-

There total 11 articles about BenzaMide, N-[1-(3,5-di-O-benzoyl-2-C-Methyl-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyriMidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 817204-35-6
N⁴-benzoyl-2'-C-methyl-β-D-arabinofuranosylcytosine

: 98-88-4
benzoyl chloride

: 863329-62-8,863329-64-0
N⁴-benzoyl-1-(2-C-methyl-3,5-di-O-benzoyl-β-D-arabinofuranosyl)cytosine

Guidance literature:: With pyridine; at 20 ℃; for 1.5h;
DOI:10.1021/jm0502788

Reference yield:

: 817204-34-5
N⁴-benzoyl-1-[2-C-methyl-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]cytosine

: 98-88-4
benzoyl chloride

: 863329-62-8,863329-64-0
N⁴-benzoyl-1-(2-C-methyl-3,5-di-O-benzoyl-β-D-arabinofuranosyl)cytosine

Guidance literature:: N⁴-benzoyl-1-[2-C-methyl-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]cytosine; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 5h;

benzoyl chloride; In tetrahydrofuran; pyridine; at 20 ℃; for 2h;

Reference yield:

: 93-97-0
benzoic acid anhydride

: 863329-62-8,863329-64-0
N⁴-benzoyl-1-(2-C-methyl-3,5-di-O-benzoyl-β-D-arabinofuranosyl)cytosine

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylformamide / 20 °C

2: dimethylformamide

3: DMSO; TFAA; TEA / -15 °C

4: diethyl ether / 2 h / -78 °C

5: 46.4 g / HOAc; tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / 20 °C

6: 67 percent / pyridine / 1.5 h / 20 °C

With pyridine; TEA; tetrabutyl ammonium fluoride; acetic acid; dimethyl sulfoxide; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 3: Swern oxidation;
DOI:10.1021/jm0502788