Mazapertine

Base Information

Chemical Name:Mazapertine
CAS No.:134208-17-6
Molecular Formula:C26H35N3O2
Molecular Weight:421.583
Hs Code.:
UNII:N0X1XW704P
DSSTox Substance ID:DTXSID40158594
Nikkaji Number:J587.525K
Wikipedia:Mazapertine
Wikidata:Q15426196
NCI Thesaurus Code:C174731
Pharos Ligand ID:SV42RQNHQPYG
ChEMBL ID:CHEMBL10085
Mol file:134208-17-6.mol

Synonyms:Mazapertine;134208-17-6;Mazapertine [INN];UNII-N0X1XW704P;piperidin-1-yl-[3-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]phenyl]methanone;CHEMBL10085;N0X1XW704P;RWJ-377796;D01WJZ;MAZAPERTINE [WHO-DD];SCHEMBL636631;DTXSID40158594;BDBM50029257;EN300-6503749;L001470;Q15426196;Z2161394331;Piperidino[3-[[4-(2-isopropoxyphenyl)piperazino]methyl]phenyl] ketone;(3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)phenyl)(piperidin-1-yl)methanone;{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-phenyl}-piperidin-1-yl-methanone;1-(.ALPHA.-(4-(O-ISOPROPOXYPHENYL)-1-PIPERAZINYL)-M-TOLUOYL)PIPERIDINE;1-[3-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]benzoyl]piperidine;1-{[3-(piperidine-1-carbonyl)phenyl]methyl}-4-[2-(propan-2-yloxy)phenyl]piperazine;PIPERIDINE, 1-(3-((4-(2-(1-METHYLETHOXY)PHENYL)-1-PIPERAZINYL)METHYL)BENZOYL)-

Suppliers and Price of Mazapertine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MAZAPERTINE 95.00%
5MG
$ 496.54

Total 1 raw suppliers

Chemical Property of Mazapertine

Chemical Property:

Vapor Pressure:1.29E-13mmHg at 25°C
Boiling Point:583.8°Cat760mmHg
Flash Point:306.9°C
PSA：36.02000
Density:1.128g/cm³
LogP:4.36290
XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:421.27292737
Heavy Atom Count:31
Complexity:555

Purity/Quality:: MAZAPERTINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)OC1=CC=CC=C1N2CCN(CC2)CC3=CC(=CC=C3)C(=O)N4CCCCC4
Uses Antipsychotic.

Technology Process of Mazapertine

There total 5 articles about Mazapertine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 134208-17-6
1-[3-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]benzoyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: iPr₂NEt / tetrahydrofuran / 1 h / Ambient temperature

2: tetrahydrofuran / 1.) RT, overnight, 2.) reflux, 7 h

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jm970164z

Reference yield:

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 134208-17-6
1-[3-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]benzoyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: iPr₂NEt / tetrahydrofuran / 1 h / Ambient temperature

2: tetrahydrofuran / 1.) RT, overnight, 2.) reflux, 7 h

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jm970164z