4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one

Base Information

Chemical Name:4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one
CAS No.:913720-11-3
Molecular Formula:C₁₀H₈FNO
Molecular Weight:177.178
Hs Code.:

Synonyms:4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one;4'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one

Suppliers and Price of 4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one

There total 4 articles about 4'-fluoro-Spiro[cyclopropane-1,3'-[3H]indol]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 138343-94-9
4-fluoro-1,3-dihydro-2H-indol-2-one

: 106-93-4
ethylene dibromide

: 913720-11-3
4'-fluorospiro[cyclopropane-1,3'-indoline]-2'-one

Guidance literature:: 4-fluoro-1,3-dihydro-2H-indol-2-one; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -20 - 0 ℃;

ethylene dibromide; In tetrahydrofuran; at 0 - 20 ℃; for 15 - 18h;

Reference yield: 82.0%

: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid amide

: 913720-11-3
4'-fluorospiro[cyclopropane-1,3'-indoline]-2'-one

Guidance literature:: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid amide; With lithium hydride; In N,N-dimethyl-formamide; at 120 ℃; for 4h;

With hydrogenchloride; water; In N,N-dimethyl-formamide; Product distribution / selectivity;

Reference yield: 82.0%

: 138343-94-9
4-fluoro-1,3-dihydro-2H-indol-2-one

: diphenyl(vinyl)sulfonium trifluoromethanesulfonate

: 913720-11-3
4'-fluorospiro[cyclopropane-1,3'-indoline]-2'-one

Guidance literature:: With zinc trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 21 ℃; for 4h;
DOI:10.1039/C6RA24985J