4-(CHLOROMETHYL)-2-[(4-FLUOROPHENOXY)METHYL]-1,3-THIAZOLE

Base Information

• Chemical Name: 4-(CHLOROMETHYL)-2-[(4-FLUOROPHENOXY)METHYL]-1,3-THIAZOLE
• CAS No.: 871497-65-3
• Molecular Formula: C₁₁H₉ClFNOS
• Molecular Weight: 257.716
• Mol file: 871497-65-3.mol

Synonyms:4-(CHLOROMETHYL)-2-[(4-FLUOROPHENOXY)METHYL]-1,3-THIAZOLE

Chemical Property of 4-(CHLOROMETHYL)-2-[(4-FLUOROPHENOXY)METHYL]-1,3-THIAZOLE

Chemical Property:

• PSA: 50.36000
• LogP: 3.60000

Purity/Quality:

98% ^*data from raw suppliers

4-(Chloromethyl)-2-((4-fluorophenoxy)methyl)thiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(CHLOROMETHYL)-2-[(4-FLUOROPHENOXY)METHYL]-1,3-THIAZOLE

There total 2 articles about 4-(CHLOROMETHYL)-2-[(4-FLUOROPHENOXY)METHYL]-1,3-THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-Fluoro-phenoxy)-thioacetamide (35370-93-5) + 1,3-Dichloroacetone (534-07-6) → C11H9ClFNOS (871497-65-3)

Guidance literature:

In acetonitrile; at 70 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmcl.2022.128602

Reference yield:

4-Fluorophenol (371-41-5) → C11H9ClFNOS (871497-65-3)

Guidance literature:

Multi-step reaction with 3 steps

1: anhydrous sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 8 h / 60 °C

2: phosphorous pentasulfide / ethanol / 5 h / 20 °C

3: acetonitrile / 6 h / 70 °C / Inert atmosphere

With phosphorous pentasulfide; anhydrous sodium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2022.128602

upstream raw materials:

4-Fluorophenol

2-(4-Fluoro-phenoxy)-thioacetamide

1,3-Dichloroacetone

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