1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine
• CAS No.: 183208-54-0
• Molecular Formula: C₁₀H₁₂BrN₃
• Molecular Weight: 254.129
• Hs Code.: 2933990090
• Mol file: 183208-54-0.mol

Synonyms:1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine

Chemical Property of 1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 340.63°C at 760 mmHg
• Flash Point: 159.808°C
• PSA: 31.92000
• Density: 1.514g/cm³
• LogP: 2.38700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine

There total 1 articles about 1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine (183208-54-0)

Guidance literature:

In butan-1-ol; for 0.666667h; Reflux;

Reference yield: 81.0%

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine (183208-54-0) → 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (757978-33-9)

Guidance literature:

With hexamethylenetetramine; In water; propionic acid; at 140 ℃; for 5h;

Reference yield:

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine (183208-54-0) → 5-(2-phenoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:

Multi-step reaction with 4 steps

1.1: hexamethylenetetramine / water; propionic acid / 5 h / 140 °C

2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 2 h

3.1: pyridine; hydroxylamine hydrochloride / ethanol; chloroform / 6 h / Heating / reflux

3.2: Heating / reflux

4.1: sodium carbonate; lithium chloride / bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 105 °C

With pyridine; sodium hydroxide; hexamethylenetetramine; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; chloroform; water; propionic acid; toluene;

upstream raw materials:

formaldehyd

N,N-dimethylammonium chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde