6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine

Base Information

• Chemical Name: 6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine
• CAS No.: 1354893-21-2
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.217
• Hs Code.: 2933990090
• Mol file: 1354893-21-2.mol

Synonyms:6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine;,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine

Chemical Property of 6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine

Chemical Property:

• PKA: 14.66±0.20(Predicted)
• PSA: 40.71000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 1.53740
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c'']dipyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine

There total 4 articles about 6,7,8,9-Tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-ethylamine (4649-12-1) → 6,7,8,9-tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine (1354893-21-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol; water; at 150 ℃; for 20h; Sealed tube;

DOI:10.1111/bph.14118

Reference yield:

7-Azaindole (271-63-6) → 6,7,8,9-tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine (1354893-21-2)

Guidance literature:

Multi-step reaction with 4 steps

1: formaldehyd / butan-1-ol / 2.5 h / 120 °C

2: dimethylsulfide; sodium methylate / methanol / 1.5 h / 0 °C

3: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 8 h / 70 °C

4: hydrogenchloride / ethanol; 1,4-dioxane; water / 20 h / 150 °C / Sealed tube

With hydrogenchloride; formaldehyd; dimethylsulfide; 20% palladium hydroxide-activated charcoal; hydrogen; sodium methylate; In 1,4-dioxane; methanol; ethanol; water; butan-1-ol; 1: |Mannich Aminomethylation / 4: |Pictet-Spengler Synthesis;

DOI:10.1111/bph.14118

Reference yield:

7-azagramine (5654-92-2) → 6,7,8,9-tetrahydro-5H-pyrrolo[2,3-b:5,4-c']dipyridine (1354893-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfide; sodium methylate / methanol / 1.5 h / 0 °C

2: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 8 h / 70 °C

3: hydrogenchloride / ethanol; 1,4-dioxane; water / 20 h / 150 °C / Sealed tube

With hydrogenchloride; dimethylsulfide; 20% palladium hydroxide-activated charcoal; hydrogen; sodium methylate; In 1,4-dioxane; methanol; ethanol; water; 3: |Pictet-Spengler Synthesis;

DOI:10.1111/bph.14118

upstream raw materials:

formaldehyd

2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-ethylamine

7-Azaindole

7-azagramine

Refernces