Bis[2-(2′-broMoisobutyryloxy)ethyl]disulfide

Base Information

• Chemical Name: Bis[2-(2′-broMoisobutyryloxy)ethyl]disulfide
• CAS No.: 817637-79-9
• Molecular Formula: C₁₂H₂₀Br₂O₄S₂
• Molecular Weight: 452.228
• Hs Code.: 29319090
• Mol file: 817637-79-9.mol

Synonyms:Bis[2-(2′-broMoisobutyryloxy)ethyl]disulfide;(BiBOE)2S2;BiBOEDS

Chemical Property of Bis[2-(2′-broMoisobutyryloxy)ethyl]disulfide

Chemical Property:

• Refractive Index: n20/D1.529
• Flash Point: >110℃
• PSA: 103.20000
• Density: 1.478 g/mL at 25 °C
• LogP: 3.80120
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis[2-(2′-bromoisobutyryloxy)ethyl]disulfide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Atom Transfer Radical Polymerisation (ATRP) initiator for the preparation of biodegradable polymers as well as polymers that adhere to gold surfaces. May also be used to introduce a temperature and light sensitive cleavable region into the polymer.

Technology Process of Bis[2-(2′-broMoisobutyryloxy)ethyl]disulfide

There total 2 articles about Bis[2-(2′-broMoisobutyryloxy)ethyl]disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

bis(2-hydroxyethyl) disulfide (1892-29-1) + 2-bromoisobutyric acid bromide (20769-85-1) → bis[2-(2-bromoisobutyryloxy)ethyl] disulfide (817637-79-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 19.5h; Inert atmosphere; Cooling with ice;

DOI:10.1021/jacs.8b12072

Reference yield: 81.0%

bis(2-hydroxyethyl) disulfide (1892-29-1) + 2-bromo-2-methylpropionic acid (2052-01-9) → bis[2-(2-bromoisobutyryloxy)ethyl] disulfide (817637-79-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 25h; Cooling with ice;

DOI:10.1039/c2jm33419d

upstream raw materials:

bis(2-hydroxyethyl) disulfide

2-bromoisobutyric acid bromide

2-bromo-2-methylpropionic acid