Pyrazine, 2,3-dichloro-5-(Methylthio)-

Base Information

• Chemical Name: Pyrazine, 2,3-dichloro-5-(Methylthio)-
• CAS No.: 1174517-48-6
• Molecular Formula: C5H4Cl2N2S
• Molecular Weight: 195.06966
• Mol file: 1174517-48-6.mol

Synonyms:Pyrazine, 2,3-dichloro-5-(Methylthio)-;2,3-Dichloro-5-(methylthio)pyrazine;2,3-dichloro-5-(methylsulfanyl)pyrazine

Chemical Property of Pyrazine, 2,3-dichloro-5-(Methylthio)-

Chemical Property:

• PSA: 51.08000
• LogP: 2.50530

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dichloro-5-(methylthio)pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of Pyrazine, 2,3-dichloro-5-(Methylthio)-

There total 1 articles about Pyrazine, 2,3-dichloro-5-(Methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,3-dichloropyrazine (4858-85-9) + methanethiosulfonic acid S-methyl ester (2949-92-0,31761-75-8) + C4HCl4LiMgN2 + TMPMgCl*LiCl → 2,3-dichloro-5-methylsulfanyl-pyrazine (1174517-48-6)

Guidance literature:

2,3-dichloropyrazine; TMPMgCl*LiCl; In tetrahydrofuran; at 25 ℃; for 0.416667h; Inert atmosphere;

methanethiosulfonic acid S-methyl ester; C₄HCl₄LiMgN₂; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol901275n

Reference yield: 72.0%

2,3-dichloro-5-methylsulfanyl-pyrazine (1174517-48-6) + TMPMgCl*LiCl + C5H3Cl4LiMgN2S + 4-fluorobenzoyl chloride (403-43-0) → (5,6-dichloro-3-methylsulfanyl-pyrazin-2-yl)-(4-fluoro-phenyl)-methanone (1174517-60-2)

Guidance literature:

2,3-dichloro-5-methylsulfanyl-pyrazine; TMPMgCl*LiCl; With zinc(II) chloride; In tetrahydrofuran; at -40 ℃; for 1h; Inert atmosphere;

C₅H₃Cl₄LiMgN₂S; 4-fluorobenzoyl chloride; With copper(I) cyanide lithium chloride; In tetrahydrofuran; at -40 - -10 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ol901275n

upstream raw materials:

2,3-dichloropyrazine

methanethiosulfonic acid S-methyl ester

Downstream raw materials:

(5,6-dichloro-3-methylsulfanyl-pyrazin-2-yl)-(4-fluoro-phenyl)-methanone

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