3-[Methoxy(triphenylmethyl)amino]propan-1-ol

Base Information

• Chemical Name: 3-[Methoxy(triphenylmethyl)amino]propan-1-ol
• CAS No.: 112510-75-5
• Molecular Formula: C23H25NO2
• Molecular Weight: 347.457
• DSSTox Substance ID: DTXSID20703400
• Wikidata: Q82635556
• Mol file: 112510-75-5.mol

Synonyms:112510-75-5;3-[methoxy(trityl)amino]propan-1-ol;3-(MONOMETHOXYTRITYLAMINO)PROPAN-1-OL;3-[Methoxy(triphenylmethyl)amino]propan-1-ol;DTXSID20703400

Chemical Property of 3-[Methoxy(triphenylmethyl)amino]propan-1-ol

Chemical Property:

• Boiling Point: 503.1±50.0 °C(Predicted)
• PKA: 14.99±0.10(Predicted)
• PSA: 41.49000
• Density: 1.111±0.06 g/cm3(Predicted)
• LogP: 4.35000
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 347.188529040
• Heavy Atom Count: 26
• Complexity: 336

Purity/Quality:

≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CON(CCCO)C(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 3-[Methoxy(triphenylmethyl)amino]propan-1-ol

There total 4 articles about 3-[Methoxy(triphenylmethyl)amino]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-<(4-methoxyphenyl)diphenylmethyl>-β-alanine benzylester (119462-96-3) → 3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol (112510-75-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1002/hlca.19880710826

Reference yield: 98.0%

propan-1-ol-3-amine (156-87-6) + mono-4-methoxytrityl chloride (14470-28-1) → 3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol (112510-75-5)

Guidance literature:

With pyridine; triethylamine; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2007.10.011

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 3-(<(4-methoxyphenyl)diphenylmethyl>amino)propanol (112510-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) TsOH; 2) N-methylmorpholine / 1) MeCN; 2) pyridine, 5 h

2: 99 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

With 4-methyl-morpholine; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1002/hlca.19880710826

upstream raw materials:

N-<(4-methoxyphenyl)diphenylmethyl>-β-alanine benzylester

propan-1-ol-3-amine

mono-4-methoxytrityl chloride

Downstream raw materials:

1-N-[3'-(4-monomethoxytrityl)amino-1'-propyloxycarbonyl]amino-6-hexanol